Publications in High Impact Journals
Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP. MT2-MMP-Dependent Release of Collagen IV NC1 Domains Regulates Submandibular Gland Branching Morphogenesis. Developmental Cell 17:482-493, 2009.
Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461:1002-1007, 2009.
Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, Koutcher JA, Spassova M, Ouerfelli O, Mellinghoff IK, Zakowski MF, Politi KA , Pao W. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. Journal of Clinical Investigation 119:3000-10, 2009.
Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell 138:961-75, 2009.
Vanacore R, Ham AL, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG. A Sulfilimine Bond Identified in Collagen IV. Science 325:1230-1234, 2009
Red Brewer M, Choi SH, Alvarado D, Moravcevic K, Pozzi A, Lemmon MA, Carpenter G. The juxtamembrane region of the EGF receptor functions as an activation domain. Molecular Cell 34:641-651, 2009
Neilson EG, Farris AB. MGH Case 21-2009: A 61-Year-Old Woman with Abdominal Pain, Weight Loss, and Renal Failure. The New England Journal of Medicine 361:179-187, 2009
Zeisberg M and Neilson EG. Biomarkers for epithelial-mesenchymal transitions. Journal of Clinical Investigation 119:1429-1437, 2009
Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. Journal of Clinical Investigation 119:1571-1582, 2009
Boothby M. The calculus of integrating differentiation: timing control of T-bet. Immunity 30:666-8, 2009
Dixon BS, Beck GJ, Vazquez MA, Greenberg A, Delmez JA, Allon M, Dember LM, Himmelfarb J, Gassman JJ, Greene T, Radeva MK, Davidson IJ, Ikizler TA, Braden GL, Fenves AZ, Kaufman JS, Cotton JR Jr, Martin KJ, McNeil JW, Rahman A, Lawson JH, Whiting JF, Hu B, Meyers CM, Kusek JW, Feldman HI; DAC Study Group. Effect of dipyridamole plus aspirin on hemodialysis graft patency. New England Journal of Medicine 360:2191-201, 2009
Moser M, Legate KR, Zent R, Fässler R. The tail of integrins, talin, and kindlins. Science 324:895-9, 2009
Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. New England Journal of Medicine 360:129-39, 2009
Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Hogg RS, Deeks SG, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Goedert JJ, Benson CA, Collier AC, Van Rompaey SE, Crane HM, McKaig RG, Lau B, Freeman AM, Moore RD; NA-ACCORD Investigators. Effect of early versus deferred antiretroviral therapy for HIV on survival. New England Journal of Medicine 360:1815-26, 2009
Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA. International Warfarin Pharmacogenetics Consortium. Estimation of the warfarin dose with clinical and pharmacogenetic data. New England Journal of Medicine 360:753-64, 2009
Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. New England Journal of Medicine 360:225-235, 2009
Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chemical Biology 5:108-17, 2009
Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME: Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. Journal of Clinical Investigation 119:986-96, 2009
Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AAM, Knollmann BC. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nature Medicine 15:380-3, 2009
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. Journal of the American Medical Association 301:489-99, 2009
Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. Journal of Clinical Investigation 119:876-85, 2009
Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB, Wen W, Levy S, Deming SL, Haines JL, Gu K, Fair AM, Cai Q, Lu W, Shu XO. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nature Genetics 41:324-8, 2009
Adler DH, Cogan JD, Phillips JA 3rd, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Journal of Clinical Investigation118:2121-31, 2008
Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF. Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis. Cell Metabolism 8:492-501, 2008
Baudenbacher F, Schober T, Pinto JR, Sidorov, VY, Hilliard F, Solaro RJ, Potter JD, Knollman BC. Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. Journal of Clinical Investigation 118:3893-903, 2008
Brantley-Sieders,D., Zhuang,G., Hicks,D.,Fang,W.B., Hwang,Y.,Cates,J., Coffman,K., Jackson,D.,Bruckheimer,E.,Muraoka-Cook,R., and Chen, J. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. Journal of Clinical Investigation 118:64-78, 2008
Christine H. Chung, Beloo Mirakhur, Emily Chan, Quyhn-Tu Le, Jordan Berlin, Mike Morse, Barbara A. Murphy, Shama Satinover, Jacob Hosen, David Mauro, Robbert J. Slebos, Qinwei Zhou, Diane Gold, Tina Hatley, Daniel J. Hicklin and Thomas A. E. Platts-Mills. Cetuximab-induced anaphylaxis and IgE antibodies against galactose-alpha-1,3-galactose. New England Journal of Medicine 358:1109-1117, 2008
Churchill LR. Bioethics Beyond the Life Span, The Lancet 371:1066-1067, 2008
Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, Himmelfarb J, Vazquez MA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW & Feldma, HI: Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial. Journal of the American Medical Association 299:2164-71, 2008
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence M, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good P, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455:1069-1075, 2008
Girard TD, Kress JP, Fuchs BD, Thomason JWW, Schweickert WD, Pun BT, Taichman DB, Dunn AG, Pohlman AS, Kinniry P, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomized controlled trial. The Lancet 371:126-134, 2008
Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Thorleifsson G, Zheng SL, Sun J, Chang BL, Elmore JB, Breyer JP, McReynolds KM, Bradley KM, Yaspan BL, Wiklund F, Stattin P, Lindstrõm S, Adami HO, McDonnell SK, Schaid DJ, Cunningham JM, Wang L, Cerhan JR, St Sauver JL, Isaacs SD, Wiley KE, Partin AW, Walsh PC, Polo S, Ruiz-Echarri M, Navarrete S, Fuertes F, Saez B, Godino J, Weijerman PC, Swinkels DW, Aben KK, Witjes JA, Suarez BK, Helfand BT, Frigge ML, Kristjansson K, Ober C, Jonsson E, Einarsson GV, Xu J, Gronberg H, Smith JR, Thibodeau SN, Isaacs WB, Catalona WJ, Mayordomo JI, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nature Genetics 40:281-3, 2008
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, Rinehart C, Seidel B, Yee D, Arteaga CL, Engelman JA. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. Journal of Clinical Investigation 118:2609-19, 2008
Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett JC Jr, Olson TM. Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. New England Journal of Medicine 359:158-65, 2008
Knollmann BC, Roden DM: A genetic framework for improving arrhythmia therapy. Nature 451:929-936, 2008
Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S, Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz PJ, George AL Jr, and Roden DM. Single common mutation in the cardiac sodium channel gene SCN5A with diverse clinical phenotypes. Journal of Clinical Investigation 118:2219-2229, 2008
Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Makiyama T, Itoh L, Christiansen M, McKeown P, Miyamoto K, Kamakura S, Tsutsui H, Schwartz PJ, George AL Jr, Roden DM: The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. Journal of Clinical Investigation 118:2219-29, 2008
Mundy GR, Yang X. Hedgehog coordination of postnatal osteoclast and osteoblast activities. Developmental Cell 14:637-8, 2008
Nyman LR, Wells KS, Head WS, McCaughey M, Ford E, Brissova M, Piston DW, Powers AC. Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. Journal of Clinical Investigation 118:3790-7, 2008
Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK; AVOID Study Investigators. Aliskiren combined with losartan in type 2 diabetes and nephropathy. New England Journal of Medicine 358:2433-46, 2008
Roden DM: Long-QT Syndrome. New England Journal of Medicine 358:169-176, 2008
Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL, Bourassa MG, Arnold JM, Buxton AE, Camm AJ, Connolly SJ, Dubuc M, Ducharme A, Guerra PG, Hohnloser SH, Lambert J, Le Heuzey JY, O'hara G, Pedersen OD, Rouleau JL, Singh BN, Stevenson LW, Stevenson WG, Thibault B, Waldo AL; Atrial Fibrillation and Congestive Heart Failure Investigators. Rhythm control versus rate control for atrial fibrillation and heart failure. New England Journal of Medicine 358:2667-77, 2008
Schwarz UI, Ritchie MD, Bradford Y, Li Chun, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM. Genetic determinants of response to warfarin during initial anticoagulation. New England Journal of Medicine 358:999-1008, 2008
Shaw LJ, Berman DS, Maron DJ, Mancini GB, Hayes SW, Hartigan PM, Weintraub WS, O'Rourke RA, Dada M, Spertus JA, Chaitman BR, Friedman J, Slomka P, Heller GV, Germano G, Gosselin G, Berger P, Kostuk WJ, Schwartz RG, Knudtson M, Veledar E, Bates ER, McCallister B, Teo KK, Boden WE; COURAGE Investigators. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation 117:1283-91, 2008
Tager AM, LaCamera P, Shea BS, Campanella GK, Kamiri-Shah BA, Kim ND, Zhao, Z, Polosukhin V, Hart WK, Poorvu EC, Bercury SD, Chun J, Blackwell TS, Xu Y, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nature Medicine 14:45-54, 2008
Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott J-J, Demolombe S, Probst V, Anselme F, Escande D, Weisfeld ACP, Pfeufer A, Kaab S, Wichmann H-E, Hasdemir C, Aizawa Y, Wilde AAM, Roden DM, Bezzina CR: Sodium Channel beta1-subunit Mutations Associated with Brugada Syndrome and Cardiac Conduction Disease. Journal of Clinical Investigation 118:2260-8, 2008
Weintraub WS, Spertus JA, Kolm P, Maron DJ, Zhang Z, Jurkovitz C, Zhang W, Hartigan PM, Lewis C, Veledar E, Bowen J, Dunbar SB, Deaton C, Kaufman S, O'Rourke RA, Goeree R, Barnett PG, Teo KK, Boden WE; COURAGE Trial Research Group, Mancini GB. New England Journal of Medicine 359:677-87, 2008
Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13:23-35, 2008
Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouzsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type 1 receptor inhibition reduces heterotopic ossification. Nature Medicine 14:1363-9, 2008
Bernard GR. PEEP guided by esophageal pressure--any added value? New England Journal of Medicine 359:2166-8, 2008.
Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA 3rd, Lansdorp PM, Greider CW, Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis. New England Journal of Medicine 356:1317-1326, 2007
Arteaga CL: HER3 and mutant EGFR meet MET. Nature Medicine 13:675-7, 2007
Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. Journal of Clinical Investigation 117:1305-13, 2007
Boden WE, O'Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G, Blaustein AS, Booth DC, Bates ER, Spertus JA, Berman DS, Mancini GB, Weintraub WS; COURAGE Trial Research Group. Optimal medical therapy with or without PCI for stable coronary disease. New England Journal of Medicine 356:1503-16, 2007
Boffetta P, Tarone RE, Blot WJ: Survival in women after diagnosis of lung cancer. Journal of the American Medical Association 297:153, 2007
Cha YI, DuBois RN. NSAIDs and cancer prevention: targets downstream of COX-2. Annual Review of Medicine 58:239-52, 2007
Chang, S and Aune, TM. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper 2 cells. Nature Immunology 8:723-731, 2007
Churchill LR, The Dangers of Looking for the Health Benefits of Religion, The Lancet 369:1509-1510, 2007
Coffey RJ, Washington MK, Corless CL, Heinrich MC. Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Journal of Clinical Investigation 117:70-80, 2007
Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fassler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H. Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell 129:179-93, 2007
Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447:959-65, 2007
Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. Journal of Clinical Investigation 117:3846-3856, 2007
Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y: When good drugs go bad. Nature 446:975-7, 2007
Kripalani S, LeFevre F, Phillips CO, Williams MV, Basaviah P, Baker DW. Deficits in communication and information transfer between hospital-based and primary care physicians: implications for patient safety and continuity of care. Journal of the American Medical Association 297:831-841, 2007
Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Journal of the American Medical Association 298:2644-2653, 2007
Venkov CD, Link AJ, Jennings JL, Inoue T, Plieth D, Dimitrova YN, Rauscher FJ, and Neilson EG: A proximal activator of transcription in epithelial-mesenchymal transition. Journal of Clinical Investigation 117:482-491, 2007
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Chu J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao, M-S, Twomey D, Verhaak RGW, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M. Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893-898, 2007
Wheeler AP, Bernard GR. Acute lung injury and the acute respiratory distress syndrome: a clinical review. The Lancet 369:1553-64, 2007
Willett WC, Blot WJ, Colditz GA, Folsom AR, Henderson BE, Stampfer MJ: Merging and emerging cohorts: not worth the wait. Nature 445: 257-258, 2007
Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AR, Neilson EG, Sayegh MH, Izumo S and Kalluri R: Endothelial to mesenchymal transition contributes to cardiac fibrosis. Nature Medicine 13:952-961, 2007
Guan Y, Zhang Y, Wu J, Qi Z, Yang G, Dou D, Gao Y, Chen L, Zhang X, Davis LS, Wei M, Fan X, Carmosino M, Hao C, Imig JD, Breyer RM, Breyer MD. Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. Journal of Clinical Investigation 117:2496-505, 2007
Arteaga CL: EGF receptor mutations in lung cancer: from humans to mice and maybe back to humans. Cancer Cell 9:421-3, 2006
Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Bruning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoprotein E-deficient mice against atherosclerosis. Cell Metabolism 3:247-56, 2006
Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Matthay MA, Ware LB, Homer RJ, Elias JA. Hyperoxia causes angiopoietin-2 mediated acute lung injury and necrotic cell death. Nature Medicine 12:1286-93, 2006
Boice JD Jr. Thyroid disease 60 years after Hiroshima and 20 years after Chernobyl. Journal of the American Medical Association 295:1060-1062, 2006
Buchanan FG, DuBois RN. Connecting COX-2 and Wnt in cancer. Cancer Cell 9:6-8, 2006
Dixon DA, Tolley ND, Bemis-Standoli K, Martinez ML, Weyrich AS, Morrow JD, Prescott SM, Zimmerman GA. Expression of COX-2 in platelet-monocyte interactions occurs via combinatiorial regulation involving adhesion and cytokine signaling. Journal of Clinical Investigation 116:2727-38, 2006
Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metabolism 4:441-51, 2006
Harris RC and Neilson EG: Towards a unified theory of renal progression. Annual Review of Medicine 57:365-380, 2006
Hebert SC. Therapeutic use of calcimimetics. Annual Review of Medicine 57:349-64, 2006
Knollmann BC, Chopra N, Hlaing T, Akin B, Yang T, Ettensohn K, Knollmann BEC, Horton KD, Weissman NJ, Holinstat IA, Zhang W, Roden DM, Jones LR, Franzini-Armstrong C, Pfeifer K: Casq2 Deletion Causes Sarcoplasmic Reticulum Volume Increase, Premature Ca2+ Release, And Catecholaminergic Polymorphic Ventricular Tachycardia. Journal of Clinical Investigation 116:2510-2520, 2006
Lang MR, Lapierre LA, Frotscher M, Goldenring JR, Knapik EW. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nature Genetics 38:1198-203, 2006
Mundy GR, Elefteriou F. Boning up on ephrin signaling. Cell 126:441-3, 2006
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. New England Journal of Medicine 354:2213-24, 2006
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL. Comparison of two fluid-management strategies in acute lung injury. New England Journal of Medicine 354:2564-75, 2006
Poehling KA, Talbot TR, Griffin MR, Craig AS, Whitney CG, Zell E, Lexau CA, Thomas AR, Harrison LH, Reingold AL, Hadler JL, Farley MM, Anderson BJ, Schaffner W. Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine. Journal of the American Medical Association 295:1668-74, 2006
Ray WA, Stein CM. Reform of drug regulation--beyond an independent drug-safety board. New England Journal of Medicine 354:194-201, 2006
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. New England Journal of Medicine 355:2542-50, 2006
Sterling TR, Haas DW. Transmission of Mycobacterium tuberculosis from health care workers. New England Journal of Medicine 355:118-21, 2006
Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL.HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 10:25-38, 2006
Zhang, F. Thomas, L.R., Oltz, E.M. and Aune, T.M. Control of thymocyte development and Rag gene expression by the zinc finger protein Zfp608. Nature Immunology 7:1309-1316, 2006
Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E Jr, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. Journal of Clinical Investigation 116:1696-702, 2006
Cosgrove SE, Fishman NO, Talbot TR, Woeltje KF, Schaffner W, Fraser VJ, McMillan JA, Perl TM. Strategies for use of a limited influenza vaccine supply. Journal of the American Medical Association 293:229-32, 2005
Cover, T. L. & Blanke, S. R. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nature Reviews Microbiology 3: 320-332, 2005
Dhawan, P., Singh, A. B., Deane, N. G., No, Y., Shiou, S. R., Schmidt, C., Neff, J., Washington, M. K., & Beauchamp, R. D. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. Journal of Clinical Investigation 115:1765-1776, 2005
Drolet B, Simard C, Mizoue L, Roden DM: Modulated access to a drug blocking site as a mechanism for drug resistance in a human cardiac potassium channel DNA polymorphism. The Journal of Clinical Investigation 115:2209-2213, 2005
Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-20, 2005
Garland, E.M., Raj, S.R. and Robertson, D. Marathon run in a patient with severe autonomic failure. The Lancet 366:S13, 2005
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