Newcomb, Dawn, Ph.D.

Dr. Dawn Newcomb
Research Assistant Professor of Medicine
Primary Department:
Department of Medicine
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center
Division of Allergy, Pulmonary & Critical Care Medicine
1161 21st Ave. South, Suite T-1218 MCN
Nashville, TN 37232-2650
Office Phone:
Phone to Schedule:
Office Fax:
Undergraduate School & Degree:
North Carolina State University
B.S., 2002
Graduate School & Degree:
University of Michigan
Ph.D., 2007

Brief Bio:

Dr. Newcomb received her undergraduate degree from North Carolina State University in 2002 and her Ph.D. from University of Michigan in 2007.  She trained as a post-doctoral fellow in Dr. R. Stokes Peebles, Jr. M.D. laboratory at Vanderbilt University focusing on lung inflammation, viral infections, and T cell immune responses.  Dr. Newcomb currently has a K12 award to determine the role of gender in CD4+ Th17-mediated inflammation in severe asthma.  


Asthma, adaptive T cell responses

Virally-induced and allergic lung inflammation

Gender and T cell differentiation


Newcomb, DC, Boswell, MG, Reiss, S, Zhou, W, Goleniewska, K, Toki, S, Harintho, MT, Lukacs, NW, Kolls, JK, Peebles, RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax, , , 2013.

Sevin, CM, Newcomb, DC, Toki, S, Han, W, Sherrill, TP, Boswell, MG, Zhu, Z, Collins, RD, Boyd, KL, Goleniewska, K, Huckabee, MM, Blackwell, TS, Peebles, RS. Deficiency of gp91phox Inhibits Allergic Airway Inflammation. Am J Respir Cell Mol Biol, , , 2013.

Tanjore, H, Degryse, AL, Crossno, PF, Xu, XC, McConaha, ME, Jones, BR, Polosukhin, VV, Bryant, AJ, Cheng, DS, Newcomb, DC, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE. ??-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am J Respir Crit Care Med, 187(6), 630-9, 2013.

Toki, S, Goleniewska, K, Huckabee, MM, Zhou, W, Newcomb, DC, Fitzgerald, GA, Lawson, WE, Peebles, RS. PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, , , 2013.

Newcomb, DC, Boswell, MG, Huckabee, MM, Goleniewska, K, Dulek, DE, Reiss, S, Lukacs, NW, Kolls, JK, Peebles, RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol, 188(3), 1027-35, 2012.

Polosukhin, VV, Degryse, AL, Newcomb, DC, Jones, BR, Ware, LB, Lee, JW, Loyd, JE, Blackwell, TS, Lawson, WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res, 38(3), 135-46, 2012.

Zhou, W, Dowell, DR, Huckabee, MM, Newcomb, DC, Boswell, MG, Goleniewska, K, Lotz, MT, Toki, S, Yin, H, Yao, S, Natarajan, C, Wu, P, Sriram, S, Breyer, RM, Fitzgerald, GA, Peebles, RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS One, 7(5), e33518, 2012.

Boswell, MG, Zhou, W, Newcomb, DC, Peebles, RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat, 96(1-4), 21-6, 2011.

Lawson, WE, Cheng, DS, Degryse, AL, Tanjore, H, Polosukhin, VV, Xu, XC, Newcomb, DC, Jones, BR, Roldan, J, Lane, KB, Morrisey, EE, Beers, MF, Yull, FE, Blackwell, TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A, 108(26), 10562-7, 2011. PMCID:3127925

Newcomb, DC, Boswell, MG, Zhou, W, Huckabee, MM, Goleniewska, K, Sevin, CM, Hershey, GK, Kolls, JK, Peebles, RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J Allergy Clin Immunol, 127(4), 1006-13.e1-4, 2011. PMCID:3127925

Zhou, W, Dowell, DR, Geraci, MW, Blackwell, TS, Collins, RD, Polosukhin, VV, Lawson, WE, Wu, P, Sussan, T, Biswal, S, Goleniewska, K, O''Neal, J, Newcomb, DC, Toki, S, Morrow, JD, Peebles, RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol, 301(4), L615-22, 2011.

Zaynagetdinov, R, Ryzhov, S, Goldstein, AE, Yin, H, Novitskiy, SV, Goleniewska, K, Polosukhin, VV, Newcomb, DC, Mitchell, D, Morschl, E, Zhou, Y, Blackburn, MR, Peebles, RS, Biaggioni, I, Feoktistov, I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am J Respir Cell Mol Biol, 42(5), 564-71, 2010. PMCID:2874442

Moore, ML, Chi, MH, Luongo, C, Lukacs, NW, Polosukhin, VV, Huckabee, MM, Newcomb, DC, Buchholz, UJ, Crowe, JE, Goleniewska, K, Williams, JV, Collins, PL, Peebles, RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J Virol, 83(9), 4185-94, 2009. PMCID:2668460

Moore, ML, Newcomb, DC, Parekh, VV, Van Kaer, L, Collins, RD, Zhou, W, Goleniewska, K, Chi, MH, Mitchell, D, Boyce, JA, Durbin, JE, Sturkie, C, Peebles, RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol, 183(3), 2016-26, 2009. PMCID:3127925

Newcomb, DC, Peebles, RS. Bugs and asthma: a different disease. Proc Am Thorac Soc, 6(3), 266-71, 2009. PMCID:2677401

Newcomb, DC, Zhou, W, Moore, ML, Goleniewska, K, Hershey, GK, Kolls, JK, Peebles, RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol, 182(9), 5317-21, 2009. PMCID:2677401

Zhou, W, Newcomb, DC, Moore, ML, Goleniewska, K, O''Neal, JF, Peebles, RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J Immunol, 181(8), 5360-7, 2008. PMCID:2668460