Dworski, Ryszard T., MD, PhD

Dr. Ryszard Dwoworski
Rank:
Associate Professor of Medicine
Primary Department:
Department of Medicine
Division:
Allergy, Pulmonary, and Critical Care Medicine
Email:
ryszard.dworski@vanderbilt.edu
Board & Certifications:

American Board of Internal Medicine, American Board of Allergy & Immunology, American Board of Pulmonary Medicine, American Board of Critical Care Medicine

Brief Bio:

Dr. Ryszard Dworski received his M.D. and Ph.D. from the prestigious Jagiellonian University in Krakow, Poland in 1980 and 1983, respectively. He was trained in Internal Medicine at the Jagiellonian University in Krakow, Poland, and Vanderbilt University in Nashville. He completed Clinical Pharmacology, Allergy and Immunology, and Pulmonary and Critical Care Fellowship programs at Vanderbilt University. His clinical interest is focused on asthma and other allergic and immune lung disorders. He investigates mechanisms of airway inflammation and the role of oxidant stress in human allergic asthma. He performs complex studies using a model of acute asthma exacerbation provoked by either inhaled or bronchoscopic allergen challenge in human asthmatics in vivo.
 

Research Focus:

asthma and allergic diseases

Publications:

Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium. Polosukhin VV, Polosukhin IV, Hoskins A, Han W, Abdolrasulnia R, Blackwell TS, Dworski R. Allergy. 2014 Dec;69(12):1666-72.

Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity.Braun NA, Celada LJ, Herazo-Maya JD, Abraham S, Shaginurova G, Sevin CM, Grutters J, Culver DA, Dworski R, Sheller J, Massion PP, Polosukhin VV, Johnson JE, Kaminski N, Wilkes DS, Oswald-Richter KA, Drake WP.
Am J Respir Crit Care Med. 2014 Sep 1;190(5):560-71.

Rapid Oral Desensitization to Everolimus. Karlin E, Allinder JM, Dworski R, Stollings JL. Ann Pharmacother. 2014 May 8;48(8):1095-1096.


Diagnostic utility of concentrated Mus m 1 allergen extract in humans. Norton A, Smith K, James K, Hoskins A, Scott TA, Plunkett G, Fahrenholz J, Dworski R. Ann Allergy Asthma Immunol. 2014 Apr;112(4):391-2.


CaMKII is essential for the proasthmatic effects of oxidation. Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Blackwell TS, Dworski R, Sammut D, Wagner BA, Buettner GR, Pope RM, Miller FJ Jr, Dibbern ME, Haitchi HM, Mohler PJ, Howarth PH, Zabner J, Kline JN, Grumbach IM, Anderson ME.

 

Hoskins, A, Reiss, S, Wu, P, Chen, N, Han, W, Do, RH, Abdolrasulnia, R, Dworski, R. Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype. Am J Respir Crit Care Med, 187(1), 34-41, 2013.

Bastarache, JA, Sebag, SC, Clune, JK, Grove, BS, Lawson, WE, Janz, DR, Roberts, LJ, Dworski, R, Mackman, N, Ware, LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax, 67(12), 1032-9, 2012.

Hoskins, A, Roberts, JL, Milne, G, Choi, L, Dworski, R. Natural-source d-??-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Allergy, 67(5), 676-82, 2012.

Majeski, E, Hoskins, A, Dworski, R, Sheller, JR. Iloprost inhalation in mild asthma. J Asthma, 49(9), 961-5, 2012.

Dworski, R, Han, W, Blackwell, TS, Hoskins, A, Freeman, ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med, 51(2), 516-21, 2011.

Dworski, R, Simon, HU, Hoskins, A, Yousefi, S. Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways. J Allergy Clin Immunol, 127(5), 1260-6, 2011.

Jones, JD, Temino, VM, Dworski, R, Anderson, CK, Fahrenholz, JM, An, AQ. Use of olopatadine ophthalmic solution and reactivity of histamine skin testing. Allergy Asthma Proc, 29(6), 636-9, 2009.

Rock, M, Yoder, S, Hoskins, A, Ajayi, WU, Ajayi, W, Sheller, JR, Dworski, R. Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma. Ann Allergy Asthma Immunol, 102(5), 432-7, 2009.

Talati, M, Meyrick, B, Peebles, RS, Davies, SS, Dworski, R, Mernaugh, R, Mitchell, D, Boothby, M, Roberts, LJ, Sheller, JR. Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med, 40(7), 1210-9, 2006.

Cruz-Gervis, R, Stecenko, AA, Dworski, R, Lane, KB, Loyd, JE, Pierson, R, King, G, Brigham, KL. Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis. Respir Res, 3, 17, 2002. PMCID:107846

Peebles, RS, Hashimoto, K, Morrow, JD, Dworski, R, Collins, RD, Hashimoto, Y, Christman, JW, Kang, KH, Jarzecka, K, Furlong, J, Mitchell, DB, Talati, M, Graham, BS, Sheller, JR. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am J Respir Crit Care Med, 165(8), 1154-60, 2002.

Sheller, J, Dworski, R, Hagaman, D, Oates, J, Murray, J. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. Prostaglandins Other Lipid Mediat, 70(1-2), 185-93, 2002.

Dworski, R, Christman, BW, Sheller, JR. Quantitative analysis of f(2) isoprostanes. Methods Mol Med, 56, 423-30, 2001.

Dworski, R, Roberts, LJ, Murray, JJ, Morrow, JD, Hartert, TV, Sheller, JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin Exp Allergy, 31(3), 387-90, 2001.

Dworski, R, Sheller, JR, Christman, BW. Quantitative analysis of cyclooxygenase metabolites of arachidonic Acid. Methods Mol Med, 56, 411-22, 2001.

Stecenko, AA, King, G, Torii, K, Breyer, RM, Dworski, R, Blackwell, TS, Christman, JW, Brigham, KL. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation, 25(3), 145-55, 2001.

Brightling, CE, Ward, R, Woltmann, G, Bradding, P, Sheller, JR, Dworski, R, Pavord, ID. Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med, 162(3 Pt 1), 878-82, 2000.

Dworski, R. Oxidant stress in asthma. Thorax, 55 Suppl 2, S51-3, 2000. PMCID:1765968

Hartert, TV, Dworski, RT, Mellen, BG, Oates, JA, Murray, JJ, Sheller, JR. Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. Am J Respir Crit Care Med, 162(2 Pt 1), 637-40, 2000.

Peebles, RS, Dworski, R, Collins, RD, Jarzecka, K, Mitchell, DB, Graham, BS, Sheller, JR. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am J Respir Crit Care Med, 162(2 Pt 1), 676-81, 2000.

Dworski, R, Murray, JJ, Roberts, LJ, Oates, JA, Morrow, JD, Fisher, L, Sheller, JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med, 160(6), 1947-51, 1999.

Morrow, JD, Zackert, WE, Yang, JP, Kurhts, EH, Callewaert, D, Dworski, R, Kanai, K, Taber, D, Moore, K, Oates, JA, Roberts, LJ. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem, 269(2), 326-31, 1999.

Dworski, R, Sheller, JR. Differential sensitivities of human blood monocytes and alveolar macrophages to the inhibition of prostaglandin endoperoxide synthase-2 by interleukin-4. Prostaglandins, 53(4), 237-51, 1997.

Dworski, RT, Funk, CD, Oates, JA, Sheller, JR. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am J Respir Crit Care Med, 155(1), 351-7, 1997.

Dworski, R, Sheller, JR. New therapies for asthma. Compr Ther, 20(11), 611-5, 1994.

Christman, BW, Christman, JW, Dworski, R, Blair, IA, Prakash, C. Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. J Immunol, 151(4), 2096-104, 1993.

Dworski, R, FitzGerald, GA, Sheller, JR. Thromboxane synthase inhibition in allergen challenged sheep lung: effect on eicosanoid synthesis. Eicosanoids, 5(1), 35-7, 1992.

Dworski, R, Sheller, J. Inhaled steroids in asthma. Compr Ther, 18(3), 3-5, 1992.

Sladek, K, Dworski, R, Fitzgerald, GA, Buitkus, KL, Block, FJ, Marney, SR, Sheller, JR. Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin. Am Rev Respir Dis, 141(6), 1441-5, 1990.

Dworski, R, Sheller, JR, Wickersham, NE, Oates, JA, Brigham, KL, Roberts, LJ, Fitzgerald, GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am Rev Respir Dis, 139(1), 46-51, 1989.