Blackwell, Timothy S., MD

Blackwell_Timothy-profile-o-ed-200x280.jpg
Rank:
Ralph and Lulu Owen Professor of Medicine

Professor of Cell and Developmental Biology

Professor of Cancer Biology

Director, DIvision of Allergy, Pulmonary and Critical Care

Primary Department:
Department of Medicine
Division:
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center
Division of Allergy, Pulmonary & Critical Care Medicine
1161 21st Ave. South, Suite T-1217 MCN
Nashville, TN 37232-2650
Office Phone:
615-343-4761
Office Fax:
615-322-2582
Email:
timothy.blackwell@vanderbilt.edu
Undergraduate School & Degree:
Vanderbilt University, B.S.
Medical School & Degree:
University of Alabama, M.D.
Board & Certifications:

Internal Medicine, Pulmonary Diseases, Critical Care Medicine

Brief Bio:

Dr. Timothy S. Blackwell received his undergraduate degree from Vanderbilt University in 1984 and his M.D. from the University of Alabama in 1988. He trained in Internal Medicine at Washington University and completed a Pulmonary and Critical Care Fellowship at Vanderbilt University. His research interests include transcriptional regulation of cytokine and chemokine production, particularly through the NF-kB transcription factor pathway. His laboratory investigates how manipulating specific signaling pathways can alter lung carcinogenesis, impact the biology of acute lung injury, and regulate pulmonary host defense functions. He is also interested in pathways that lead to resolution of inflammation and mechanisms by which abnormal repair of tissue injury leads to fibrosis.

Research Focus:

acute lung injury/ARDS, sepsis, pulmonary fibrosis, and lung cancer
 

Publications:

Recent Journal Articles:

Aldrich, MC, Munro, HM, Mumma, M, Grogan, EL, Massion, PP, Blackwell, TS, Blot, WJ. Chronic obstructive pulmonary disease and subsequent overall and lung cancer mortality in low-income adults. PLoS One, 10(3), e0121805, 2015.

Buckman, LB, Thompson, MM, Lippert, RN, Blackwell, TS, Yull, FE, Ellacott, KL. Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab, 4(1), 58-63, 2015.

Han, W, Zaynagetdinov, R, Yull, FE, Polosukhin, VV, Gleaves, LA, Tanjore, H, Young, LR, Peterson, TE, Manning, HC, Prince, LS, Blackwell, TS. Molecular Imaging of Folate Receptor ??-Positive Macrophages during Acute Lung Inflammation. Am J Respir Cell Mol Biol, 53(1), 50-9, 2015.

Kropski, JA, Blackwell, TS, Loyd, JE. The genetic basis of idiopathic pulmonary fibrosis. Eur Respir J, 45(6), 1717-27, 2015.

Wang, H, Chen, X, Su, Y, Paueksakon, P, Hu, W, Zhang, MZ, Harris, RC, Blackwell, TS, Zent, R, Pozzi, A. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int, 87(5), 948-62, 2015.

Zaynagetdinov, R, Sherrill, TP, Gleaves, LA, McLoed, AG, Saxon, JA, Habermann, AC, Connelly, L, Dulek, D, Peebles, RS, Fingleton, B, Yull, FE, Stathopoulos, GT, Blackwell, TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res, 75(8), 1624-34, 2015.

Blackwell, TS, Tager, AM, Borok, Z, Moore, BB, Schwartz, DA, Anstrom, KJ, Bar-Joseph, Z, Bitterman, P, Blackburn, MR, Bradford, W, Brown, KK, Chapman, HA, Collard, HR, Cosgrove, GP, Deterding, R, Doyle, R, Flaherty, KR, Garcia, CK, Hagood, JS, Henke, CA, Herzog, E, Hogaboam, CM, Horowitz, JC, King, TE, Loyd, JE, Lawson, WE, Marsh, CB, Noble, PW, Noth, I, Sheppard, D, Olsson, J, Ortiz, LA, O''Riordan, TG, Oury, TD, Raghu, G, Roman, J, Sime, PJ, Sisson, TH, Tschumperlin, D, Violette, SM, Weaver, TE, Wells, RG, White, ES, Kaminski, N, Martinez, FJ, Wynn, TA, Thannickal, VJ, Eu, JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med, 189(2), 214-22, 2014.

Dulek, DE, Newcomb, DC, Goleniewska, K, Cephus, J, Zhou, W, Reiss, S, Toki, S, Ye, F, Zaynagetdinov, R, Sherrill, TP, Blackwell, TS, Moore, ML, Boyd, KL, Kolls, JK, Peebles, RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 82(9), 3723-39, 2014.

He, W, Zhang, M, Zhao, M, Davis, LS, Blackwell, TS, Yull, F, Breyer, MD, Hao, CM. Increased dietary sodium induces COX2 expression by activating NF??B in renal medullary interstitial cells. Pflugers Arch, 466(2), 357-67, 2014.

Jin, R, Yi, Y, Yull, FE, Blackwell, TS, Clark, PE, Koyama, T, Smith, JA, Matusik, RJ. NF-??B gene signature predicts prostate cancer progression. Cancer Res, 74(10), 2763-72, 2014.

Paulson, NB, Gilbertsen, AJ, Dalluge, JJ, Welchlin, CW, Hughes, J, Han, W, Blackwell, TS, Laguna, TA, Williams, BJ. The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung. PLoS One, 9(10), e111441, 2014.

Plosa, EJ, Young, LR, Gulleman, PM, Polosukhin, VV, Zaynagetdinov, R, Benjamin, JT, Im, AM, van der Meer, R, Gleaves, LA, Bulus, N, Han, W, Prince, LS, Blackwell, TS, Zent, R. Epithelial ??1 integrin is required for lung branching morphogenesis and alveolarization. Development, 141(24), 4751-62, 2014.

Polosukhin, VV, Polosukhin, IV, Hoskins, A, Han, W, Abdolrasulnia, R, Blackwell, TS, Dworski, R. Glutathione S-transferase M1 modulates allergen-induced NF-??B activation in asthmatic airway epithelium. Allergy, 69(12), 1666-72, 2014.

Shi, C, Washington, MK, Chaturvedi, R, Drosos, Y, Revetta, FL, Weaver, CJ, Buzhardt, E, Yull, FE, Blackwell, TS, Sosa-Pineda, B, Whitehead, RH, Beauchamp, RD, Wilson, KT, Means, AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest, 94(4), 409-21, 2014.

Stouch, AN, Zaynagetdinov, R, Barham, WJ, Stinnett, AM, Slaughter, JC, Yull, FE, Hoffman, HM, Blackwell, TS, Prince, LS. I??B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol, 193(3), 1184-93, 2014.

Sun, X, He, S, Wara, AK, Icli, B, Shvartz, E, Tesmenitsky, Y, Belkin, N, Li, D, Blackwell, TS, Sukhova, GK, Croce, K, Feinberg, MW. Systemic delivery of microRNA-181b inhibits nuclear factor-??B activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res, 114(1), 32-40, 2014.

Talati, M, West, J, Zaynagetdinov, R, Hong, CC, Han, W, Blackwell, T, Robinson, L, Blackwell, TS, Lane, K. BMP pathway regulation of and by macrophages. PLoS One, 9(4), e94119, 2014.

Barham, W, Frump, AL, Sherrill, TP, Garcia, CB, Saito-Diaz, K, VanSaun, MN, Fingleton, B, Gleaves, L, Orton, D, Capecchi, MR, Blackwell, TS, Lee, E, Yull, F, Eid, JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov, 3(11), 1286-301, 2013.

Kropski, JA, Lawson, WE, Young, LR, Blackwell, TS. Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech, 6(1), 9-17, 2013.

Tanjore, H, Degryse, AL, Crossno, PF, Xu, XC, McConaha, ME, Jones, BR, Polosukhin, VV, Bryant, AJ, Cheng, DS, Newcomb, DC, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE. ??-Catenin in the Alveolar Epithelium Protects from Lung Fibrosis following Intratracheal Bleomycin. Am J Respir Crit Care Med, , , 2013.

Barham, W, Sherrill, T, Connelly, L, Blackwell, TS, Yull, FE. Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-??B reporter transgenic. J Vis Exp, (67), e4030, 2012.

Degryse, AL, Xu, XC, Newman, JL, Mitchell, DB, Tanjore, H, Polosukhin, VV, Jones, BR, McMahon, FB, Gleaves, LA, Phillips, JA, Cogan, JD, Blackwell, TS, Lawson, WE. Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp Lung Res, 38(3), 124-34, 2012.

Han, W, Li, H, Segal, BH, Blackwell, TS. Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp, (68), , 2012.

Kropski, JA, Lawson, WE, Blackwell, TS. Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 302(5), L441-4, 2012.

Polosukhin, VV, Degryse, AL, Newcomb, DC, Jones, BR, Ware, LB, Lee, JW, Loyd, JE, Blackwell, TS, Lawson, WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res, 38(3), 135-46, 2012.

Tanjore, H, Blackwell, TS, Lawson, WE. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 302(8), L721-9, 2012.

Tanjore, H, Lawson, WE, Blackwell, TS. Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim Biophys Acta, , , 2012.

Young, LR, Gulleman, PM, Bridges, JP, Weaver, TE, Deutsch, GH, Blackwell, TS, McCormack, FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med, 186(10), 1014-24, 2012.

Zaynagetdinov, R, Stathopoulos, GT, Sherrill, TP, Cheng, DS, McLoed, AG, Ausborn, JA, Polosukhin, VV, Connelly, L, Zhou, W, Fingleton, B, Peebles, RS, Prince, LS, Yull, FE, Blackwell, TS. Epithelial nuclear factor-I?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene, 31(26), 3164-76, 2012.

Blackwell, TS, Hipps, AN, Yamamoto, Y, Han, W, Barham, WJ, Ostrowski, MC, Yull, FE, Prince, LS. NF-{kappa}B Signaling in Fetal Lung Macrophages Disrupts Airway Morphogenesis. J Immunol, 187(5), 2740-7, 2011.

Connelly, L, Barham, W, Onishko, HM, Chen, L, Sherrill, TP, Zabuawala, T, Ostrowski, MC, Blackwell, TS, Yull, FE. NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast Cancer Res, 13(4), R83, 2011. PMCID:3236346

Connelly, L, Barham, W, Onishko, HM, Sherrill, T, Chodosh, LA, Blackwell, TS, Yull, FE. Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene, 30(12), 1402-12, 2011.

Degryse, AL, Tanjore, H, Xu, XC, Polosukhin, VV, Jones, BR, Boomershine, CS, Ortiz, C, Sherrill, TP, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE. TGF{beta} signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am J Physiol Lung Cell Mol Physiol, 300(6), L887-97, 2011.

Dworski, R, Han, W, Blackwell, TS, Hoskins, A, Freeman, ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med, , , 2011.

Grimm, MJ, Vethanayagam, RR, Almyroudis, NG, Lewandowski, D, Rall, N, Blackwell, TS, Segal, BH. Role of NADPH oxidase in host defense against aspergillosis. Med Mycol, 49 Suppl 1, S144-9, 2011. PMCID:2936383

Lawson, WE, Blackwell, TS, Gauldie, J. Let It Be: microRNAs Impact Interstitial Lung Disease. Am J Respir Crit Care Med, 183(1), 1-2, 2011.

Lawson, WE, Cheng, DS, Degryse, AL, Tanjore, H, Polosukhin, VV, Xu, XC, Newcomb, DC, Jones, BR, Roldan, J, Lane, KB, Morrisey, EE, Beers, MF, Yull, FE, Blackwell, TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A, , , 2011.

Phillips, JA, Cogan, JD, Austin, ED, Larkin, EK, Markin, CR, Lawson, WE, Newman, JH, Loyd, JE, Blackwell, TS. Differences in Average Age of Onset, Locus Heterogeneity, and Penetrance between Familial Pulmonary Arterial Hypertension and Familial Interstitial Pneumonia Can Predict the Success of Linkage and Whole Exome Sequencing in Discovering Disease-Causing Alleles. Proc Am Thorac Soc, 8(2), 205-6, 2011.

Polosukhin, VV, Cates, JM, Lawson, WE, Milstone, AP, Matafonov, AG, Massion, PP, Lee, JW, Randell, SH, Blackwell, TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J Pathol, 224(2), 203-11, 2011.

Polosukhin, VV, Cates, JM, Lawson, WE, Zaynagetdinov, R, Milstone, AP, Massion, PP, Ocak, S, Lee, JW, Bowler, RP, Kononov, AV, Randell, SH, Blackwell, TS. Bronchial Secretory IgA Deficiency Correlates With Airway Inflammation and Progression of COPD. Am J Respir Crit Care Med, , , 2011.

Tanjore, H, Cheng, DS, Degryse, AL, Zoz, DF, Abdolrasulnia, R, Lawson, WE, Blackwell, TS. Alveolar epithelial cells undergo epithelial to mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem, , , 2011.

Zaynagetdinov, R, Sherrill, TP, Polosukhin, VV, Han, W, Ausborn, JA, McLoed, AG, McMahon, FB, Gleaves, LA, Degryse, AL, Stathopoulos, GT, Yull, FE, Blackwell, TS. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J Immunol, 187(11), 5703-11, 2011.

Zhou, W, Dowell, DR, Geraci, MW, Blackwell, TS, Collins, RD, Polosukhin, VV, Lawson, WE, Wu, P, Sussan, T, Biswal, S, Goleniewska, K, O''Neal, J, Newcomb, DC, Toki, S, Morrow, JD, Peebles, RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol, 301(4), L615-22, 2011. PMCID:3236346

Zoz, DF, Lawson, WE, Blackwell, TS. Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. Am J Med Sci, 341(6), 435-8, 2011.

Benjamin, JT, Carver, BJ, Plosa, EJ, Yamamoto, Y, Miller, JD, Liu, JH, van der Meer, R, Blackwell, TS, Prince, LS. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol, 185(8), 4896-903, 2010.

Connelly, L, Barham, W, Pigg, R, Saint-Jean, L, Sherrill, T, Cheng, DS, Chodosh, LA, Blackwell, TS, Yull, FE. Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. J Cell Physiol, 222(1), 73-81, 2010. PMCID:2783968

Crossno, PF, Polosukhin, VV, Blackwell, TS, Johnson, JE, Markin, C, Moore, PE, Worrell, JA, Stahlman, MT, Phillips, JA, Loyd, JE, Cogan, JD, Lawson, WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest, 137(4), 969-73, 2010.

Degryse, AL, Tanjore, H, Xu, XC, Polosukhin, VV, Jones, BR, McMahon, FB, Gleaves, LA, Blackwell, TS, Lawson, WE. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol, 299(4), L442-52, 2010. PMCID:2936383

Doris, K, Karabela, SP, Kairi, CA, Simoes, DC, Roussos, C, Zakynthinos, SG, Kalomenidis, I, Blackwell, TS, Stathopoulos, GT. Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice. Respir Res, 11, 118, 2010. PMCID:2936383

Kobayashi, H, Huang, J, Ye, F, Shyr, Y, Blackwell, TS, Lin, PC. Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. PLoS One, 5(3), e9458, 2010. PMCID:2832764

Lee, HJ, Joo, M, Abdolrasulnia, R, Young, DG, Choi, I, Ware, LB, Blackwell, TS, Christman, BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem, 285(51), 39655-62, 2010.

Psallidas, I, Karabela, SP, Moschos, C, Sherrill, TP, Kollintza, A, Magkouta, S, Theodoropoulou, P, Roussos, C, Blackwell, TS, Kalomenidis, I, Stathopoulos, GT. Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study. Mol Cancer, 9, 56, 2010. PMCID:2841124

Psallidas, I., Karabela, S.P., Moschos, C., Sherrill, T.P., Kollintza, A., Magkouta, S., Theodoropoulou, P., Roussos, C., Blackwell, T.S., Kalomenidis, I., Stathopoulos, G.T. . Speficic effects of bortezomib against experimental malignant pleural effusion: a preclinical study.. Mol. Cancer, 9, 56, 2010.

Role of NADPH oxidase in host defense against Aspergillus.. Grimm, M.J., Vethanayagam, R.R., Almyroudis, N.G., Lewandowski, D., Rall, N., Blackwell, T.S., Segal, B.H. . Medical Mycology, , , 2010.

Segal, B.H., Han, W., Bushey, J.J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C.G., Vethanayagam, R.R., Yull, F.E., Capitano, M., Wallace, P.K., Minderman, H., Christman, J.W., Sporn, M.B., Chan, J., Vinh, D.C., Holland, S.M., Romani, L.R., Gaffen, S.L., Freeman, M.L., Blackwell, T.S. . NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice.. PLoS One , 5(3), e9631, 2010.

Segal, BH, Han, W, Bushey, JJ, Joo, M, Bhatti, Z, Feminella, J, Dennis, CG, Vethanayagam, RR, Yull, FE, Capitano, M, Wallace, PK, Minderman, H, Christman, JW, Sporn, MB, Chan, J, Vinh, DC, Holland, SM, Romani, LR, Gaffen, SL, Freeman, ML, Blackwell, TS. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One, 5(3), e9631, 2010. PMCID:2838778

Stathopoulos, G.T., Sherrill, T.P., Karabela, S.P., Goleniewska, K., Kalomenidis, I., Roussos, C., Fingleton, B., Yull, F.E., Peebles, R.S., Blackwell, T.S. . Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.. Am. J. Respir. Crit. Care Med., , , 2010.

Stathopoulos, GT, Sherrill, TP, Karabela, SP, Goleniewska, K, Kalomenidis, I, Roussos, C, Fingleton, B, Yull, FE, Peebles, RS, Blackwell, TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am J Respir Crit Care Med, 182(10), 1273-81, 2010. PMCID:2936383

Williams, B.J., Du, R.-H., Calcull, W., Abdolrasulnia, R., Christman, B.W., Blackwell, T.S.. Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa.. Mol. Microbiol, , , 2010.

Williams, BJ, Dehnbostel, J, Blackwell, TS. Pseudomonas aeruginosa: host defence in lung diseases. Respirology, 15(7), 1037-56, 2010. PMCID:2936383

Bastarache, JA, Blackwell, TS. Development of animal models for the acute respiratory distress syndrome. Dis Model Mech, 2(5-6), 218-23, 2009. PMCID:2675821

Boomershine, CS, Chamberlain, A, Kendall, P, Afshar-Sharif, AR, Huang, H, Washington, MK, Lawson, WE, Thomas, JW, Blackwell, TS, Bhowmick, NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut, 58(9), 1267-74, 2009. PMCID:2719085

Han, W, Joo, M, Everhart, MB, Christman, JW, Yull, FE, Blackwell, TS. Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol, 296(3), L320-7, 2009. PMCID:2660215

Ma, LL, Gao, X, Liu, L, Xiang, Z, Blackwell, TS, Williams, P, Chari, RS, Yin, DP. CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance. Liver Transpl, 15(8), 915-23, 2009. PMCID:2817947

Sadagopal, S, Braunstein, M, Hager, CC, Wei, J, Daniel, AK, Bochan, MR, Crozier, I, Smith, NE, Gates, HO, Barnett, L, Van Kaer, L, Price, JO, Blackwell, TS, Kalams, SA, Kernodle, DS. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS One, 4(5), e5531, 2009. PMCID:2677452

Sheller, JR, Polosukhin, VV, Mitchell, D, Cheng, DS, Peebles, RS, Blackwell, TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res, 35(10), 883-95, 2009. PMCID:2832764

Tanjore, H, Xu, XC, Polosukhin, VV, Degryse, AL, Li, B, Han, W, Sherrill, TP, Plieth, D, Neilson, EG, Blackwell, TS, Lawson, WE. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med, 180(7), 657-65, 2009. PMCID:2719085

Chen, SM, Cheng, DS, Williams, BJ, Sherrill, TP, Han, W, Chont, M, Saint-Jean, L, Christman, JW, Sadikot, RT, Yull, FE, Blackwell, TS. The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin Exp Immunol, 153(3), 420-8, 2008. PMCID:2527362

Jin, RJ, Lho, Y, Connelly, L, Wang, Y, Yu, X, Saint Jean, L, Case, TC, Ellwood-Yen, K, Sawyers, CL, Bhowmick, NA, Blackwell, TS, Yull, FE, Matusik, RJ. The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res, 68(16), 6762-9, 2008. PMCID:2840631

Joo, M, Kwon, M, Azim, AC, Sadikot, RT, Blackwell, TS, Christman, JW. Genetic determination of the role of PU.1 in macrophage gene expression. Biochem Biophys Res Commun, 372(1), 97-102, 2008. PMCID:2494535

Lawson, WE, Crossno, PF, Polosukhin, VV, Roldan, J, Cheng, DS, Lane, KB, Blackwell, TR, Xu, C, Markin, C, Ware, LB, Miller, GG, Loyd, JE, Blackwell, TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol, 294(6), L1119-26, 2008.

Lewis, CC, Yang, JY, Huang, X, Banerjee, SK, Blackburn, MR, Baluk, P, McDonald, DM, Blackwell, TS, Nagabhushanam, V, Peters, W, Voehringer, D, Erle, DJ. Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med, 177(4), 376-87, 2008. PMCID:2258439

Ma, L, Xiang, Z, Sherrill, TP, Wang, L, Blackwell, TS, Williams, P, Chong, A, Chari, R, Yin, DP. Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation. Transplantation, 85(6), 903-10, 2008. PMCID:2632578

Musiek, ES, Brooks, JD, Joo, M, Brunoldi, E, Porta, A, Zanoni, G, Vidari, G, Blackwell, TS, Montine, TJ, Milne, GL, McLaughlin, B, Morrow, JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J Biol Chem, , , 2008. PMCID:2459280

Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Yull, FE, Blackwell, TS, Fingleton, B. Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol Cancer Res, 6(3), 364-71, 2008.

Tager, AM, LaCamera, P, Shea, BS, Campanella, GS, Selman, M, Zhao, Z, Polosukhin, V, Wain, J, Karimi-Shah, BA, Kim, ND, Hart, WK, Pardo, A, Blackwell, TS, Xu, Y, Chun, J, Luster, AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med, 14(1), 45-54, 2008.

Tager, AM, Lacamera, P, Shea, BS, Campanella, GS, Selman, M, Zhao, Z, Polosukhin, V, Wain, J, Karimi-Shah, BA, Kim, ND, Hart, WK, Poorvu, EC, Brooks, SF, Bercury, SD, Pardo, A, Blackwell, TS, Xu, Y, Chun, J, Luster, AD. The Lysophosphatidic Acid Receptor LPA1 Links Pulmonary Fibrosis to Lung Injury by Mediating Fibroblast Recruitment and Vascular Leak. Proc Am Thorac Soc, 5(3), 363, 2008.

Cheng, DS, Han, W, Chen, SM, Sherrill, TP, Chont, M, Park, GY, Sheller, JR, Polosukhin, VV, Christman, JW, Yull, FE, Blackwell, TS. Airway epithelium controls lung inflammation and injury through the NF-kappaB pathway. J Immunol, 178(10), 6504-13, 2007.

Connelly, L, Robinson-Benion, C, Chont, M, Saint-Jean, L, Li, H, Polosukhin, VV, Blackwell, TS, Yull, FE. A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. J Biol Chem, 282(13), 10028-35, 2007.

Glasgow, SC, Ramachandran, S, Blackwell, TS, Mohanakumar, T, Chapman, WC. Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice. Am J Physiol Lung Cell Mol Physiol, 293(2), L491-6, 2007.

Joo, M, Kwon, M, Sadikot, RT, Kingsley, PJ, Marnett, LJ, Blackwell, TS, Peebles, RS, Urade, Y, Christman, JW. Induction and function of lipocalin prostaglandin D synthase in host immunity. J Immunol, 179(4), 2565-75, 2007.

Joo, M, Wright, JG, Hu, NN, Sadikot, RT, Park, GY, Blackwell, TS, Christman, JW. Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. Am J Physiol Lung Cell Mol Physiol, 292(5), L1219-26, 2007.

Kalomenidis, I, Stathopoulos, GT, Barnette, R, Papiris, S, Blackwell, TS, Roussos, C, Light, RW. Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability. Respir Med, 101(2), 223-9, 2007.

Park, GY, Hu, N, Wang, X, Sadikot, RT, Yull, FE, Joo, M, Stokes Peebles, R, Blackwell, TS, Christman, JW. Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. Clin Exp Immunol, 150(2), 245-54, 2007. PMCID:2219354

Polosukhin, VV, Lawson, WE, Milstone, AP, Egunova, SM, Kulipanov, AG, Tchuvakin, SG, Massion, PP, Blackwell, TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch, 451(4), 793-803, 2007.

Sadikot, RT, Zeng, H, Azim, AC, Joo, M, Dey, SK, Breyer, RM, Peebles, RS, Blackwell, TS, Christman, JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunol, 37(4), 1001-9, 2007.

Stathopoulos, GT, Kollintza, A, Moschos, C, Psallidas, I, Sherrill, TP, Pitsinos, EN, Vassiliou, S, Karatza, M, Papiris, SA, Graf, D, Orphanidou, D, Light, RW, Roussos, C, Blackwell, TS, Kalomenidis, I. Tumor necrosis factor-alpha promotes malignant pleural effusion. Cancer Res, 67(20), 9825-34, 2007.

Stathopoulos, GT, Sherrill, TP, Cheng, DS, Scoggins, RM, Han, W, Polosukhin, VV, Connelly, L, Yull, FE, Fingleton, B, Blackwell, TS. Epithelial NF-{kappa}B activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A, 104(47), 18514-9, 2007. PMCID:2141808

Stathopoulos, GT, Sherrill, TP, Han, W, Sadikot, RT, Polosukhin, VV, Fingleton, B, Yull, FE, Blackwell, TS. Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin Exp Metastasis, , , 2007.

Zhang, H, Lawson, WE, Polosukhin, VV, Pozzi, A, Blackwell, TS, Litingtung, Y, Chiang, C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol, 171(4), 1113-26, 2007. PMCID:1988863

Zhou, W, Blackwell, TS, Goleniewska, K, O'Neal, JF, Fitzgerald, GA, Lucitt, M, Breyer, RM, Peebles, RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol, 81(3), 809-17, 2007.

Zhou, W, Hashimoto, K, Goleniewska, K, O'Neal, JF, Ji, S, Blackwell, TS, Fitzgerald, GA, Egan, KM, Geraci, MW, Peebles, RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol, 178(2), 702-10, 2007.