Rice, Todd , MD, MSc

Assistant Professor of Medicine
Primary Department:
Department of Medicine
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center
1161 21st. Ave. S., T-1218 MCN
Nashville, TN 37232-2650
Office Phone:
Office Fax:

Brief Bio:

Dr. Rice graduated from the University of Notre Dame with a Bachelor of Science in Biological Sciences degree and from the Indiana University School of Medicine. He completed Internal Medicine residency at the Indiana University School of Medicine and was chosen to serve as a Chief Resident in Internal Medicine there. Subsequently, he completed Pulmonary and Critical Care Medicine training at Vanderbilt University where he also got a Master’s of Science in Clinical Investigation.

Dr. Rice is a member of the American Thoracic Society, American College of Chest Physicians, and the Society of Critical Care Medicine. He is also an investigator in the National Institutes of Health ARDS Network. His research interests include sepsis, critical care nutrition, and acute lung injury, resulting in more than 30 publications and book chapters. He has an NIH-funded K23 mentored career-development grant investigating the effects of target enteral feeding on inflammation in patients with respiratory failure. Dr. Rice has delivered National and International lectures in critical care nutrition and acute lung injury. He currently serves as the Associate Director of the Vanderbilt medical ICU.


critical care medicine, sepsis, acute lung injury/ARDS, nutrition in critically ill patients

Research Focus:

nutrition in critically ill patients, sepsis, acute lung injury



Rice, TW. ACP Journal Club. Hypoglycemia was associated with increased mortality in ICU patients regardless of glucose control strategy. Ann Intern Med, 158(2), JC3, 2013.

Bastarache, JA, Ware, LB, Girard, TD, Wheeler, AP, Rice, TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr, 36(6), 732-40, 2012.

Janz, DR, Hollenbeck, RD, Pollock, JS, McPherson, JA, Rice, TW. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med, 40(12), 3135-9, 2012.

Rice, TW, Morris, S, Tortella, BJ, Wheeler, AP, Christensen, MC. Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*. Crit Care Med, 40(3), 778-86, 2012.

Rice, TW, Rubinson, L, Uyeki, TM, Vaughn, FL, John, BB, Miller, RR, Higgs, E, Randolph, AG, Smoot, BE, Thompson, BT, , . Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med, 40(5), 1487-98, 2012.

Luo, YF, Robbins, IM, Karatas, M, Brixey, AG, Rice, TW, Light, RW. Frequency of pleural effusions in patients with pulmonary arterial hypertension associated with connective tissue diseases. Chest, 140(1), 42-7, 2011.

Pugh, ME, Robbins, IM, Rice, TW, West, J, Newman, JH, Hemnes, AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant, 30(8), 904-11, 2011.

Rice, TW, Mogan, S, Hays, MA, Bernard, GR, Jensen, GL, Wheeler, AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med, 39(5), 967-74, 2011.

Rice, TW, Ware, LB, Haponik, EF, Chiles, C, Wheeler, AP, Bernard, GR, Steingrub, JS, Hite, RD, Matthay, MA, Wright, P, Ely, EW, , . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care, 15(2), R86, 2011.

Rice, TW, Wheeler, AP, Thompson, BT, deBoisblanc, BP, Steingrub, J, Rock, P, , , , . Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA, 306(14), 1574-81, 2011.

Hemnes, AR, Newman, AL, Rosenbaum, B, Barrett, TW, Zhou, C, Rice, TW, Newman, JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur Respir J, 35(4), 735-41, 2010.

Rice, TW, Wheeler, AP, Bernard, GR, Vincent, JL, Angus, DC, Aikawa, N, Demeyer, I, Sainati, S, Amlot, N, Cao, C, Ii, M, Matsuda, H, Mouri, K, Cohen, J. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med, 38(8), 1685-94, 2010.

Wheeler, AP, Rice, TW. Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing. Chest, 137(1), 185-94, 2010.

Lancaster, LH, Mason, WR, Parnell, JA, Rice, TW, Loyd, JE, Milstone, AP, Collard, HR, Malow, BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 136(3), 772-8, 2009.

Pandharipande, PP, Shintani, AK, Hagerman, HE, St Jacques, PJ, Rice, TW, Sanders, NW, Ware, LB, Bernard, GR, Ely, EW. Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score. Crit Care Med, 37(4), 1317-21, 2009.

Rice, TW, Wheeler, AP. Coagulopathy in critically ill patients: part 1: platelet disorders. Chest, 136(6), 1622-30, 2009.

Rice, TW. The historical, ethical, and legal background of human-subjects research. Respir Care, 53(10), 1325-9, 2008.

Rice, TW. How to do human-subjects research if you do not have an institutional review board. Respir Care, 53(10), 1362-7, 2008.

Fremont, RD, Rice, TW. Splenosis: a review. South Med J, 100(6), 589-93, 2007.

Rice, TW, Wheeler, AP, Bernard, GR, Hayden, DL, Schoenfeld, DA, Ware, LB, , . Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest, 132(2), 410-7, 2007.

Rice, TW, Bernard, GR. Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design. Clin Chest Med, 27(4), 733-54; abstract xi, 2006.

Rice, TW, Rodriguez, RM, Barnette, R, Light, RW. Prevalence and characteristics of pleural effusions in superior vena cava syndrome. Respirology, 11(3), 299-305, 2006.

Rice, TW, Rodriguez, RM, Light, RW. The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine (Baltimore), 85(1), 37-42, 2006.

Rice, TW, Wheeler, AP, Morris, PE, Paz, HL, Russell, JA, Edens, TR, Bernard, GR. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis. Crit Care Med, 34(9), 2271-81, 2006.

Rice, TW, Bernard, GR. Therapeutic intervention and targets for sepsis. Annu Rev Med, 56, 225-48, 2005.

Rice, TW, Bernard, GR. New additions to the intensive care armamentarium. Drugs Today (Barc), 40(2), 157-70, 2004.

Rice, TW, Bernard, GR. Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shock. Am J Med Sci, 328(4), 205-14, 2004.

Rice, TW, Milstone, AP. Chylothorax as a result of chronic lymphocytic leukemia: case report and review of the literature. South Med J, 97(3), 291-4, 2004.

Rice, TW, Swope, T, Bozeman, S, Wheeler, AP. Variation in enteral nutrition delivery in mechanically ventilated patients. Nutrition, 21(7-8), 786-92, 2004.