Hemnes, Anna R., MD

Dr. Anna Hemnes
Assistant Professor of Medicine
Assistant Director Pulmonary Vascular Center
Primary Department:
Department of Medicine
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center
1161 21st Ave S, T-1218, MCN
Nashville, TN 37232
Office Phone:
Office Fax:

Brief Bio:

Dr. Anna R. Hemnes received her undergraduate degree from Columbia University in 1995 and her M.D. from Johns Hopkins in 1999. She completed her Internal Medicine residency and fellowship in Pulmonary and Critical Care Medicine at Johns Hopkins as well. She received advanced training in pulmonary vascular disease at Vanderbilt and has incorporated this interest into her research focus: physiology of pulmonary vascular disease. Her laboratory investigates how the right ventricle hypertrophies and fails in the load stress of pulmonary hypertension and the influence of gender on this phenotype. She is also interested in the non-invasive diagnosis and evaluation of pulmonary vascular disease ranging from pulmonary embolism to pulmonary arterial and venous hypertension.


pulmonary vascular disease

Research Focus:

right ventricular hypertrophy and failure in load stress such as pulmonary hypertension, non-invasive diagnosis and evaluation of pulmonary vascular disease


Austin, ED, Hamid, R, Hemnes, AR, Loyd, JE, Blackwell, T, Yu, C, Phillips Iii, JA, Gaddipati, R, Gladson, S, Gu, E, West, J, Lane, KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ, 3(1), 6, 2012. PMCID:3310853

Brittain, EL, Hemnes, AR, Keebler, M, Lawson, M, Byrd, BF, Disalvo, T. Right ventricular plasticity and functional imaging. Pulm Circ, 2(3), 309-26, 2012.

Fessel, JP, Hamid, R, Wittmann, BM, Robinson, LJ, Blackwell, T, Tada, Y, Tanabe, N, Tatsumi, K, Hemnes, AR, West, JD. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ, 2(2), 201-13, 2012. PMCID:3401874

Hemnes, AR, Maynard, KB, Champion, HC, Gleaves, L, Penner, N, West, J, Newman, JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ, 2(3), 352-8, 2012.

Johnson, JA, Hemnes, AR, Perrien, DS, Schuster, M, Robinson, LJ, Gladson, S, Loibner, H, Bai, S, Blackwell, TR, Tada, Y, Harral, JW, Talati, M, Lane, KB, Fagan, KA, West, J. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol, 302(5), L474-84, 2012. PMCID:3310853

Larkin, EK, Newman, JH, Austin, ED, Hemnes, AR, Wheeler, L, Robbins, IM, West, JD, Phillips, JA, Hamid, R, Loyd, JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med, 186(9), 892-6, 2012.

Pugh, ME, Buchowski, MS, Robbins, IM, Newman, JH, Hemnes, AR. Physical Activity Limitation as Measured by Accelerometry in Pulmonary Arterial Hypertension. Chest, , , 2012. PMCID:3401874

West, J, Niswender, KD, Johnson, JA, Pugh, ME, Gleaves, L, Fessel, JP, Hemnes, AR. A potential role for Insulin resistance in experimental pulmonary hypertension. Eur Respir J, , , 2012.

Austin, ED, Menon, S, Hemnes, AR, Robinson, LR, Talati, M, Fox, KL, Cogan, JD, Hamid, R, Hedges, LK, Robbins, I, Lane, K, Newman, JH, Loyd, JE, West, J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ, 1(3), 389-98, 2011. PMCID:3224431

Hemnes, AR, Pugh, ME, Newman, AL, Robbins, IM, Tolle, J, Austin, ED, Newman, JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest, 140(5), 1267-73, 2011. PMCID:3112229

Johnson, JA, West, J, Maynard, KB, Hemnes, AR. ACE2 improves right ventricular function in a pressure overload model. PLoS One, 6(6), e20828, 2011. PMCID:3112229

Lane, KL, Talati, M, Austin, E, Hemnes, AR, Johnson, JA, Fessel, JP, Blackwell, T, Mernaugh, RL, Robinson, L, Fike, C, Roberts, LJ, West, J. Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ, 1(1), 72-83, 2011. PMCID:3167174

Pugh, ME, Robbins, IM, Rice, TW, West, J, Newman, JH, Hemnes, AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant, 30(8), 904-11, 2011. PMCID:3129440

Robbins, IM, Hemnes, AR, Gibbs, JS, Christman, BW, Howard, L, Meehan, S, Cabrita, I, Gonzalez, R, Oyler, T, Zhao, L, Du, RH, Mendes, LA, Wilkins, MR. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp Lung Res, 37(1), 26-34, 2011. PMCID:3077035

Hemnes, AR, Newman, AL, Rosenbaum, B, Barrett, TW, Zhou, C, Rice, TW, Newman, JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur Respir J, 35(4), 735-41, 2010. PMCID:2757639

Pugh, ME, Hemnes, AR. Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease. Womens Health (Lond Engl), 6(2), 285-96, 2010. PMCID:2853883

Pugh, ME, Hemnes, AR. Pulmonary hypertension in women. Expert Rev Cardiovasc Ther, 8(11), 1549-58, 2010. PMCID:3077035

Pugh, ME, Hemnes, AR. Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man. Int J Clin Pract Suppl, (168), 5-13, 2010. PMCID:2965027

Hemnes, AR, Bertram, A, Sisson, SD. Impact of medical residency on knowledge of asthma. J Asthma, 46(1), 36-40, 2009. PMCID:2757639

Hemnes, AR, Doyle, TP, Janssen, D, Robbins, IM. Congenital pulmonary artery stenoses masquerading as chronic thromboembolic disease. J Heart Lung Transplant, 28(10), 1110-1, 2009. PMCID:2757639

Hemnes, AR, Forfia, PR, Champion, HC. Assessment of pulmonary vasculature and right heart by invasive haemodynamics and echocardiography. Int J Clin Pract Suppl, (162), 4-19, 2009. PMCID:2757639

Hemnes, AR, Robbins, IM. Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation. Liver Transpl, 15(1), 15-9, 2009. PMCID:2716716

Robbins, IM, Newman, JH, Johnson, RF, Hemnes, AR, Fremont, RD, Piana, RN, Zhao, DX, Byrne, DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest, 136(1), 31-6, 2009. PMCID:2716716

Hemnes, AR, Champion, HC. Right heart function and haemodynamics in pulmonary hypertension. Int J Clin Pract Suppl, (160), 11-9, 2008. PMCID:2716716