Christman, Brian W., M.D.

Dr. Brian Christman
Professor of Medicine

Vice-Chair, Dept of Medicine

Chief, Medical Service, VA TN Valley Health System

Primary Department:
Deptartment of Medicine
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center,
Division of Allergy, Pulmonary & Critical Care Medicine
1161 21st Ave. South, Suite T-1218 MCN
Nashville, TN 37232-2650
Office Phone:
Office Fax:
Undergraduate School & Degree:
Tulane University
B.S. Biochemistry
Medical School & Degree:
Univ. of Oklahoma

Brief Bio:

Dr. Christman received his undergraduate degree from the Tulane University in 1977 and his M.D from the University of Oklahoma in 1981. He trained in Internal Medicine at Vanderbilt University from 1981-1984, and completed a Pulmonary and Critical Care Fellowship at Vanderbilt University from 1984-1987. He attends a weekly pulmonary consultation outpatient clinic at the Vanderbilt Clinic. Dr. Christman currently directs the fellowship training program at Vanderbilt. His research interests include: (1) investigation into the role of the urea cycle (as an arginine source for nitric oxide synthase) in acute lung injury, the post-bone marrow transplant idiopathic pneumonia syndrome, and in hepatic venocclusive, (2) role of oxidant stress in the pathogenesis of primary pulmonary hypertension, and (3) hemodynamic and ventilator management of ARDS.


Lung Injury after Bone Marrow Transplantation
Prostaglandin biology
Gas Chromatography/Mass spectrometry

Research Focus:

My research has focused on the role of eicosanoid mediators in the pathophysiology of two pulmonary diseases: acute lung injury and primary pulmonary hypertension. In combined clinical and basic studies (NIH 55198), we have examined patterns of cell activation and oxidant stress after bone marrow transplantation to decipher mechanisms of acute lung injury that occur in these patients. We've also been exploring indices of tissue macrophage activation in patients with primary pulmonary hypertension.

Recent studies have examined the importance of oxidant-associated dysfunction of the hepatic urea cycle and liver-lung injury after chemotherapy.

Recent Publications:

Robbins, IM, Hemnes, AR, Gibbs, JS, Christman, BW, Howard, L, Meehan, S, Cabrita, I, Gonzalez, R, Oyler, T, Zhao, L, Du, RH, Mendes, LA, Wilkins, MR. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp Lung Res, 37(1), 26-34, 2011.

Lee, HJ, Joo, M, Abdolrasulnia, R, Young, DG, Choi, I, Ware, LB, Blackwell, TS, Christman, BW. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Biol Chem, 285(51), 39655-62, 2010.

Robbins, IM, Kawut, SM, Yung, D, Reilly, MP, Lloyd, W, Cunningham, G, Loscalzo, J, Kimmel, SE, Christman, BW, Barst, RJ. A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension. Eur Respir J, 27(3), 578-84, 2006.

Smith, HA, Canter, JA, Christian, KG, Drinkwater, DC, Scholl, FG, Christman, BW, Rice, GD, Barr, FE, Summar, ML. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J Thorac Cardiovasc Surg, 132(1), 58-65, 2006.

Kallianpur, AR, Hall, LD, Yadav, M, Byrne, DW, Speroff, T, Dittus, RS, Haines, JL, Christman, BW, Summar, ML. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant, 35(12), 1155-64, 2005.

Robbins, IM, Morrow, JD, Christman, BW. Oxidant stress but not thromboxane decreases with epoprostenol therapy. Free Radic Biol Med, 38(5), 568-74, 2005.

Siore, AM, Parker, RE, Stecenko, AA, Cuppels, C, McKean, M, Christman, BW, Cruz-Gervis, R, Brigham, KL. Endotoxin-induced acute lung injury requires interaction with the liver. Am J Physiol Lung Cell Mol Physiol, 289(5), L769-76, 2005.

Summar, ML, Barr, F, Dawling, S, Smith, W, Lee, B, Singh, RH, Rhead, WJ, Sniderman King, L, Christman, BW. Unmasked adult-onset urea cycle disorders in the critical care setting. Crit Care Clin, 21(4 Suppl), S1-8, 2005.

Wong, F, Bernardi, M, Balk, R, Christman, B, Moreau, R, Garcia-Tsao, G, Patch, D, Soriano, G, Hoefs, J, Navasa, M, , . Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut, 54(5), 718-25, 2005. PMCID:1774473

Chen, Jian-xiong, Lawrence, Mayme Lee, Cunningham, Gary, Christman, Brian W, Meyrick, Barbara. HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium. J Appl Physiol, 96(2), 612-20, 2004.

Humbert, M, Morrell, NW, Archer, SL, Stenmark, KR, MacLean, MR, Lang, IM, Christman, BW, Weir, EK, Eickelberg, O, Voelkel, NF, Rabinovitch, M. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol, 43(12 Suppl S), 13S-24S, 2004.

Kallianpur, Asha R, Hall, Lynn D, Yadav, Meeta, Christman, Brian W, Dittus, Robert S, Haines, Jonathan L, Parl, Fritz F, Summar, Marshall L. Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer. Cancer Epidemiol Biomarkers Prev, 13(2), 205-12, 2004.

Richard, C, Gao, J, LaFleur, B, Christman, BW, Anderson, J, Brown, N, Reese, J. Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am J Physiol Regul Integr Comp Physiol, 287(3), R652-60, 2004.

Summar, ML, Hall, L, Christman, B, Barr, F, Smith, H, Kallianpur, A, Brown, N, Yadav, M, Willis, A, Eeds, A, Cermak, E, Summar, S, Wilson, A, Arvin, M, Putnam, A, Wills, M, Cunningham, G. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol Genet Metab, 81 Suppl 1, S12-9, 2004.

Summar, Marshall L, Gainer, James V, Pretorius, Mias, Malave, Hector, Harris, Stephanie, Hall, Lynn D, Weisberg, Alec, Vaughan, Douglas E, Christman, Brian W, Brown, Nancy J. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Hypertension, 43(2), 186-91, 2004.

Barr, FE, Beverley, H, VanHook, K, Cermak, E, Christian, K, Drinkwater, D, Dyer, K, Raggio, NT, Moore, JH, Christman, B, Summar, M. Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J Pediatr, 142(1), 26-30, 2003.

Chen, Daohong, Balyakina, Elena V, Lawrence, Mayme, Christman, Brian W, Meyrick, Barbara. Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 284(4), L614-21, 2003.

Chen, Jian-Xiong, Berry, Leonard C, Christman, Brian W, Meyrick, Barbara. Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation. J Cell Physiol, 197(1), 86-93, 2003.

Langleben, David, Christman, Brian W, Barst, Robyn J, Dias, Virgil C, Gali??, Nazzareno, Higenbottam, Timothy W, Kneussl, Meinhard, Korducki, Larry, Naeije, Robert, Riedel, Axel, Simonneau, Gerald, Hirsch, Andrew M, Rich, Stuart, Robbins, Ivan M, Oudiz, Ronald, McGoon, Michael D, Badesch, David B, Levy, Robert D, Mehta, Sanjay, Seeger, Werner, Sol??r, Markus. Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension. Am Heart J, 143(5), E4, 2002.

Blackwell, T S, Christman, J W, Hagan, T, Price, P, Edens, T, Morris, P E, Wolff, S N, Goodman, S A, Christman, B W. Oxidative stress and NF-kappaB activation: correlation in patients following allogeneic bone marrow transplantation. Antioxid Redox Signal, 2(1), 93-102, 2001.

Chen, J X, Berry, L C, Christman, B W, Tanner, M, Myers, P R, Meyrick, B O. NO regulates LPS-stimulated cyclooxygenase gene expression and activity in pulmonary artery endothelium. Am J Physiol Lung Cell Mol Physiol, 280(3), L450-7, 2001.

Collins, B J, Blum, M G, Parker, R E, Chang, A C, Blair, K S, Zorn, G L, Christman, B W, Pierson, R N. Thromboxane mediates pulmonary hypertension and lung inflammation during hyperacute lung rejection. J Appl Physiol, 90(6), 2257-68, 2001.

Dworski, R, Christman, BW, Sheller, JR. Quantitative analysis of f(2) isoprostanes. Methods Mol Med, 56, 423-30, 2001.

Dworski, R, Sheller, JR, Christman, BW. Quantitative analysis of cyclooxygenase metabolites of arachidonic Acid. Methods Mol Med, 56, 411-22, 2001.

Klings, E S, Christman, B W, McClung, J, Stucchi, A F, McMahon, L, Brauer, M, Farber, H W. Increased F2 isoprostanes in the acute chest syndrome of sickle cell disease as a marker of oxidative stress. Am J Respir Crit Care Med, 164(7), 1248-52, 2001.

Pearson, D L, Dawling, S, Walsh, W F, Haines, J L, Christman, B W, Bazyk, A, Scott, N, Summar, M L. Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. N Engl J Med, 344(24), 1832-8, 2001.

Robbins, I M, Barst, R J, Rubin, L J, Gaine, S P, Price, P V, Morrow, J D, Christman, B W. Increased levels of prostaglandin D(2) suggest macrophage activation in patients with primary pulmonary hypertension. Chest, 120(5), 1639-44, 2001.

Haselton, D J, Klekamp, J G, Christman, B W, Barr, F E. Use of high-dose corticosteroids and high-frequency oscillatory ventilation for treatment of a child with diffuse alveolar hemorrhage after bone marrow transplantation: case report and review of the literature. Crit Care Med, 28(1), 245-8, 2000.

Mangialardi, R J, Martin, G S, Bernard, G R, Wheeler, A P, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 28(9), 3137-45, 2000.