Loyd, James E., MD

Dr. James Loyd
Professor of Medicine
Director, Familial Primary Pulmonary Arterial Hypertension Registry
Director, Familial Idiopathic Pulmonary Fibrosis Registry
Primary Department:
Department of Medicine
Allergy, Pulmonary, and Critical Care Medicine
Office Address:
Vanderbilt University Medical Center

Division of Allergy, Pulmonary & Critical Care Medicine

1161 21st Ave. South, Suite T-1218 MCN

Nashville, TN 37232-2650


Office Phone:
Phone to Schedule:
Office Fax:
Undergraduate School & Degree:
West Virginia University - BS
Medical School & Degree:
West Virginia University - MD

Brief Bio:

Dr. Jim Loyd received his undergraduate degree from West Virginia University in 1969 and his M.D from WVU in 1973. He trained in Internal Medicine at Vanderbilt from 1973 - 1978, except for an sojourn to the US Navy from 1974-76. He completed a Pulmonary and Critical Care Fellowship at Vanderbilt University in 1981, and after an extended fellowship in England, joined the Vanderbilt faculty in 1983.


Idiopathic Pulmonary Fibrosis (IPF); Familial IPF; Interstitial Lung Disease; Fibrosing Mediastinitis; Mediastinal complications of Histoplasmosis; and Lung Transplantation

Research Focus:

Familial Idiopathic Pulmonary Fibrosis (IPF)
Familial Pulmonary Arterial Hypertension

Multicenter treatment trials for IPF;
Multicenter treatment trials for Lung Transplant



Austin, ED, Hamid, R, Hemnes, AR, Loyd, JE, Blackwell, T, Yu, C, Phillips Iii, JA, Gaddipati, R, Gladson, S, Gu, E, West, J, Lane, KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ, 3(1), 6, 2012. PMCID:3310853

Austin, ED, Ma, L, Leduc, C, Berman Rosenzweig, E, Borczuk, A, Phillips, JA, Palomero, T, Sumazin, P, Kim, HR, Talati, MH, West, J, Loyd, JE, Chung, WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet, 5(3), 336-43, 2012.

Larkin, EK, Newman, JH, Austin, ED, Hemnes, AR, Wheeler, L, Robbins, IM, West, JD, Phillips, JA, Hamid, R, Loyd, JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med, 186(9), 892-6, 2012.

Lee, HY, Seo, JB, Steele, MP, Schwarz, MI, Brown, KK, Loyd, JE, Talbert, J, Schwartz, DA, Lynch, DA. The High-Resolution CT scan Findings in Familial Interstitial Pneumonia Do Not Conform to Those of Idiopathic Interstitial Pneumonia. Chest, , , 2012.

Polosukhin, VV, Degryse, AL, Newcomb, DC, Jones, BR, Ware, LB, Lee, JW, Loyd, JE, Blackwell, TS, Lawson, WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res, 38(3), 135-46, 2012.

Albers, EL, Pugh, ME, Hill, KD, Wang, L, Loyd, JE, Doyle, TP. Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis. Circulation, 123(13), 1391-9, 2011. PMCID:3095436

Austin, ED, Menon, S, Hemnes, AR, Robinson, LR, Talati, M, Fox, KL, Cogan, JD, Hamid, R, Hedges, LK, Robbins, I, Lane, K, Newman, JH, Loyd, JE, West, J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ, 1(3), 389-98, 2011. PMCID:3224431

Fessel, JP, Loyd, JE, Austin, ED. The genetics of pulmonary arterial hypertension in the post-BMPR2 era. Pulm Circ, 1(3), 305-19, 2011. PMCID:3224422

Lawson, WE, Loyd, JE, Degryse, AL. Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. Am J Med Sci, 341(6), 439-43, 2011. PMCID:3103077

Loyd, JE. Pulmonary arterial hypertension: insights from genetic studies. Proc Am Thorac Soc, 8(2), 154-7, 2011. PMCID:3131832

Majka, S, Hagen, M, Blackwell, T, Harral, J, Johnson, JA, Gendron, R, Paradis, H, Crona, D, Loyd, JE, Nozik-Grayck, E, Stenmark, KR, West, J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res, 12, 84, 2011. PMCID:3141420

Austin, ED, Rock, MT, Mosse, CA, Vnencak-Jones, CL, Yoder, SM, Robbins, IM, Loyd, JE, Meyrick, BO. T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Respir Med, 104(3), 454-62, 2010. PMCID:2826574

Crossno, PF, Polosukhin, VV, Blackwell, TS, Johnson, JE, Markin, C, Moore, PE, Worrell, JA, Stahlman, MT, Phillips, JA, Loyd, JE, Cogan, JD, Lawson, WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest, 137(4), 969-73, 2010. PMCID:2851554

Hamid, R, Hedges, LK, Austin, E, Phillips, JA, Loyd, JE, Cogan, JD. Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension. Clin Genet, 77(3), 280-6, 2010. PMCID:2851554

Johnson, JA, Loyd, JE, Wheat, LJ, Netterville, JL. A case series and review of histoplasmosis infection in the neck. Arch Otolaryngol Head Neck Surg, 136(9), 916-9, 2010. PMCID:3095436

Talati, M, West, J, Blackwell, TR, Loyd, JE, Meyrick, B. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Am J Physiol Lung Cell Mol Physiol, 299(3), L363-73, 2010. PMCID:2951074

Austin, ED, Loyd, JE, Phillips, JA. Genetics of pulmonary arterial hypertension. Semin Respir Crit Care Med, 30(4), 386-98, 2009. PMCID:2762975

Austin, ED, Phillips, JA, Cogan, JD, Hamid, R, Yu, C, Stanton, KC, Phillips, CA, Wheeler, LA, Robbins, IM, Newman, JH, Loyd, JE. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir Res, 10, 87, 2009. PMCID:2762975

Johnson, JA, Vnencak-Jones, CL, Cogan, JD, Loyd, JE, West, J. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. BMC Med Genet, 10, 58, 2009. PMCID:2706815

Lancaster, LH, Mason, WR, Parnell, JA, Rice, TW, Loyd, JE, Milstone, AP, Collard, HR, Malow, BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest, 136(3), 772-8, 2009. PMCID:2775994

Thomas, LD, Milstone, AP, Miller, GG, Loyd, JE, Stephen Dummer, J. Long-term outcomes of cytomegalovirus infection and disease after lung or heart-lung transplantation with a delayed ganciclovir regimen. Clin Transplant, 23(4), 476-83, 2009. PMCID:2706815