RELATED TOPICS   
The SPORE in Breast Cancer  
Breast Cancer
Research Program
 

Research Description

 

Dr. Arteaga's Clinical Trials

 

Honors & Awards

 
PubMed Listing  

Carlos L. Arteaga, M.D.

Donna S. Hall Chair in Breast Cancer Research
American Cancer Society Clinical Research Professor
Professor of Medicine and Cancer Biology
Associate Director for Clinical Research
Director, Center for Cancer Targeted Therapies
Director, Breast Cancer Program

 

Carlos L. Arteaga obtained his M.D. degree with honors in 1980 at the Facultad the Ciencias Médicas of the University of Guayaquil in Guayaquil, Ecuador. He trained in Internal Medicine and Medical Oncology at Emory University (Atlanta, GA) and the University of Texas Health Sciences Center in San Antonio, TX, respectively. He joined Vanderbilt in 1989 where he now holds the Donna S. Hall Chair in Breast Cancer Research and serves as Professor of Medicine and Cancer Biology. Dr. Arteaga is also Associate Director for Translational/Clinical Research at the Vanderbilt-Ingram Cancer Center (VICC) where he leads the Breast Cancer Program and the recently founded Center for Cancer Targeted Therapies. He has over 250 publications in the areas of signaling by growth factor receptors and oncogenes in breast tumor cells, development of targeted therapies and biomarkers of drug action or resistance in breast cancer, and investigator-initiated clinical trials. His work includes the first demonstration that blockade of IGF-I receptor results in an antitumor effect in breast cancer; the first observation that tumor-host TGFb-mediated interactions are critical for breast tumor establishment and metastatic progression, thus providing a basis for the targeting of TGFb in cancers with a therapeutic intent; one of the first observations that loss of tumor suppressor PTEN confers resistance to ERBB receptor-targeted therapies; the role of p27 haploinsufficiency in breast cancer progression; and the role of PI3K signaling on resistance to antiestrogens in breast cancer.

Since 2002, he has directed the NCI-funded Vanderbilt Breast Cancer Specialized Program of Research Excellence (SPORE) where he co-leads several investigator-initiated clinical trials. He is funded by the National Cancer Institute, the American Cancer Society, the Department of Defense Breast Cancer Research Program, Stand Up 2 Cancer (SU2C) and the Susan G. Komen for the Cure and Breast Cancer Research Foundations. He is a member of the American Society of Clinical Investigation (1998) and the Association of American Physicians (2005). He served as member of the Experimental Therapeutics-2 NIH Study Section (1998-2003), the NCI Board of Scientific Counselors (1999-2004), NCI Parent Subcommittee A for review of Cancer Centers (2004-2008), the Breast Core Committee of the Eastern Cooperative Oncology Group (ECOG), and the Board of Directors of the American Association for Cancer Research (2004-2007). He co-chaired the former Developmental Therapeutics Committee of ECOG and chaired the AACR Special Conferences Committee (2002-2008). Arteaga is the recipient of the 2003 AACR Richard & Hinda Rosenthal Award, the 2007-2017 ACS Clinical Research Professor Award, the 2009 Gianni Bonadonna Award from the American Society of Clinical Oncology (ASCO) and the 2011 Brinker Award for Scientific Distinction from the Susan G. Komen for the Cure Foundation. As of this year, he serves in the Scientific Advisory Board of the Susan G. Komen for tehe Cure Breast Cancer Foundation. He co-chaired the AACR Special Conference ‘Advances in Breast Cancer Research’ in 2003, 2005, 2007, 2009 and 2013. He has served as AACR co-chair of the annual San Antonio Breast Cancer Symposium since 2009. He is Deputy Editor of Clinical Cancer Research and member of the Editorial Board of Cancer Cell and six other peer-reviewed journals. He serves on the advisory boards of several NCI Breast Cancer Research Programs and NCI-designated Cancer Centers. In 2013, he was elected as President Elect of the American Association for Cancer Research.

 

 

Education

Facultad de Ciencias Medicas Universidad de Guayaquil Ecuador, M.D.

 

Residency

Emory University

 

Fellowship

University of Texas Health Science Center at San Antonio

 

Board Certifications

Internal Medicine, Medical Oncology

 

Research Specialty

- Oncogene signaling in breast development/transformation and breast cancer progression.

- Mechanisms of resistance to targeted therapies in breast cancer.

- Novel clinical trials in breast cancer.

 

 

Administrative Contact Information

             
Vanderbilt-Ingram Cancer Center  
683 Preston Research Building  
Nashville, TN  37232  
Phone:  615-936-3524  
Fax:  615-343-1790  
Administrative Assistant: Pamela Johnson  

Email:  pamela.johnson@Vanderbilt.Edu