Edward Siew, M.D., MSCI

Associate Professor of Medicine
Primary Department:
Nephrology and Hypertension
Office Address:
Vanderbilt University School of Medicine
1161 21st Avenue South
S-3223 Medical Center North
Nashville TN 37232-2372
Office Phone:
Phone to Schedule:
Office Fax:
Undergraduate School & Degree:
The Johns Hopkins University, BA, Biology
Medical School & Degree:
The University of Chicago Pritzker School of Medicine, MD
Board & Certifications:

University of California, San Francisco, Internal Medicine
University of Pittsburgh School of Medicine, Critical Care Medicine Fellowship
Vanderbilt University Medical School, Nephrology Fellowship
Vanderbilt University Medical School, MSCI

ABIM & Subspecialty:


Internal Medicine
Critical Care

Research Focus:

Our main research interest surrounds the translational and epidemiologic study of Acute Kidney Injury (AKI). Specific areas of focus include the use of biomarkers for the early detection, phenotyping, and prognosis of this disease; the impact of AKI on long-term kidney function and overall health; and the use of biomedical informatics to help improve delivery of care to patients hospitalized with AKI.


Experimental Articles:

1. Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA. Insulin Resistance is Associated with Skeletal Muscle Protein Breakdown in Non-Diabetic Chronic Hemodialysis Patients. Kidney International, 2007 Jan; 71(2):146-152. Epub 2006 Oct 25. PMID: 17063174

2. Hung AH, Pupim, LB, Majchrzak KM, Yu, C, Shintani, A, Siew, E, Ayus, C, Hakim, RH, Ikizler, TA. Determinants of C-Reactive Protein in Chronic Hemodialysis Patients: Relevance of Dialysis Catheter Utilization. Hemodialysis International 2008; 12:235-243. PMID: 18394058

3. Siew ED, Ware LB, Gebretsadik T, Shintani A, Moon KG, Wickersham N, Bossert F, Ikizler TA. Urine Neutrophil Gelatinase-Associated Lipocalin Moderately Predicts Acute Kidney Injury in Critically Ill Adults. J Am Soc Nephrol. 2009 Aug;20(8):1823-32. Epub 2009 Jul 23. PMCID: PMC2723988

4. Hung AM, Crawford D, Griffin, MR, Brown, K, Lipkowitz, MS, Siew, ED, et al. CRP Polymorphisms and Progression of Chronic Kidney Disease in African Americans. Clin J Am Soc Nephrol 2010 Jan;5(1):24-33. PMID: 20025857

5. Siew ED, Matheny ME, Ikizler TA, Lewis JB, Miller RA, Waitman LR, Go AS, Parikh CR, Peterson JF. Commonly Used Surrogates for Baseline Renal Function Can Impact Acute Kidney Injury Classification and Prognosis. Kidney Int 2010 Mar;77(6):536-42. PMCID: PMC2929703

6. Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Parikh CR, May AK, Ware LB. Elevated Urinary IL-18 Levels at the Time of ICU Admission Predict Adverse Clinical Outcomes. Clin J Am Soc Nephrol 2010 Jun 17 (epub). PMCID: PMC2924408

7. Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ. Early Postoperative Statin Therapy is Associated with a Lower Incidence of Acute Kidney Injury Following Cardiac Surgery. J Cardiothorac Vasc Anesth. 2010 Jul 2. (epub). PMCID: PMC2992577

8. Go AS, Parikh CR, Ikizler TA, Coca SG, Siew ED, et al. The Assessment, Serial Evaluation, and Subsequent Sequlae of Acute Kidney Injury (ASSESS-AKI) Study: Design and Methods. BMC Nephrol. 2010 Aug 27;11(1):22 PMCID: PMC2944247

9. Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, Wurfel M, Himmelfarb J, Zager RA. Monocyte Chemoattractant Protein-1 and Associated Gene Activating Histone Marks as Tools for Studying Experimental and Clinical Acute Kidney Injury. J Am Soc Nephrol 2010 (in press)

10. Haase, M, Deverajan, P, Haase-Fielitz, A, Bellomo, R, Cruz, DN, Wagener, G, Krawczeski, CD, Koyner, JL, Murray, P, Zappitelli, M, Goldstein, SL, Konstantinos, M, Ronco, C Martensson, J, Martling, CR, Siew, E, Ware, LB, Ikizler, TA, Merterns PR. The Outcome of Neutrophil Gelatinase-Associated Lipocalin (NGAL)-positive Subclinical Acute Kidney Injury: A Multicenter Pooled Analysis of Prospective Studies. J Am Coll Cardiol 2011 Apr 26:57(17):1752-61 PMID: 21511111

11. O’Neal HR Jr, Koyama T, Koehler EA, Siew E, Curtis BR, Fremont RD, May AK, Bernard GR, Ware LB. Prehospital Statin and Aspirin Use and the Prevalence of Severe Sepsis and Acute Lung Injury/Acute Respiratory Distress Syndrome. Crit Care Med. 2011 Feb 17 (epub). PMCID: PMC3102130

12. Hung AM, Sundell MB, Egbert P, Siew ED, Shintani A, Ellis CD, Bian A, Ikizler TA. A Comparison of Novel and Commonly-Used Indices of Insulin Sensitivity in African American Chronic Hemodialysis Patients. Clin J Am Soc Nephrol. 2011 Apr; 6(4):767-74. PMCID: PMC3069368

13. Hung AM, Ikizler TA, Griffin MR, Clenn K, Greevy RA, Grijalva CB, Siew ED, Crawford DC. CRP Polymorphisms and Chronic Kidney Disease in the Third National Health and Nutrition Examination Survey. BMC Med Gent. 2011 May 11;12:65. PMCID: PMC3119179

14. Siew, ED, Peterson, JF, Eden, SK, Hung, AM, Speroff, T, Ikizler, TA, Matheny, ME. Outpatient Nephrology Referral Rates After Acute Kidney Injury. J Am Soc Nephrol 2012 Feb;23(2):305-12. Epub 2011 PMCID: PMC3269178

15. Siew ED, Peterson JF, Eden SK, Moons KG, Ikizler TA, Matheny ME. Use of Multiple Imputation Method to Improve Estimation of Missing Baseline Serum Creatinine in Acute Kidney Injury Research. Clin J Am Soc Nephrol PMCID: PMC3531649

16. McCoy AB, Cox ZL, Neal EB, Waitman LR, Peterson NB, Bhave G, Siew ED, Danciu I, Lewis JB, Peterson JF. Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. Appl Clin Inform. 2012 Jan 1;3(2):221-238. Epub Jun 13. PMCID: PMC3377180

17. Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA. A Pilot Study of Active Vitamin D Administration and Insulin Resistance in African American Patients Undergoing Chronic Hemodialysis. J Ren Nutr. 2012 Sep 6. PMCID: PMC3519966

18. Siew ED, Ikizler, TA, Matheny, ME, Shi, Y, Schildcrout, JS, Danciu, I, Dwyer, JP, Srichai, M, Hung, AM, Smith, JP, Peterson, JF. Estimating Baseline Kidney Function in Hospitalized Patients with Impaired Kidney Function. 2012, Clin J Am Soc Nephrol May 2012 7(5):712-9. Epub 2012 Mar 15. PMCID: PMC3338282

19. Siew ED, Peterson, JF, Eden SK, Moons KG, Ikizler TA, Matheny ME.  Use of Multiple Imputation to Improve Estimation of Missing Baseline Serum Creatinine in Acute Kidney Injury Research.  Clin J Am Soc Nephrol 2012; Oct 4 [Epub} PMCID:  PMC3531649

20. Deger, SM, Sundell MD, Siew ED, Egbert P, Ellis CD, Sh F, Ikizler TA, Hung AM. Insulin Resistance and Protein Metabolism in Chronic Hemodialysis Patients.  J Ren Nutr. 2012 PMID: 231948402013

21. Cox, ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF.  Adverse Drug Events During AKI and Its Recovery.  Clin J Am Soc Nephrol.  2013 Mar 28.  PMID:  23539228

22. Siew, ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA Distinct Injury Markers for the Early Detection and Prognosis of Incident Acute Kidney Injury in Critically Ill Adults with Preserved Kidney Function.  Kidney Int, 2013 May 22.

Non-Experimental Manuscripts:

1. Siew ED, Ikizler TA. Determinants of Insulin Resistance and its Effects on Protein Metabolism in Patients with Advanced Chronic Kidney Disease. Contrib Nephrol. 2008;161:138-44. PMID:18451670.

2. Siew ED, Ikizler TA. Insulin Resistance and Protein Energy Metabolism in Patients with Advanced Chronic Kidney Disease. Semin Dial. 2010 Jul-Aug;23(4):378-82. PMID: 20701717

3. Siew ED, Ware LB, Ikizler TA. Biological Markers of Acute Kidney Injury J Am Soc Nephrol 2011; May; 22(5):810-20. PMID: 21493774

4. Siew ED. Blind men and elephants and the biological markers of AKI. J Am Soc Nephrol. 2011 Sep;22(9):1578-80. Epub 2011 Aug 11. No abstract available. PMID: 21836142

5. Matheny ME, Siew ED, Resnic FS, Speroff T, Peterson JF, Brown JR. Risk Factors for Acute Kidney Injury Following Cardiac Catheterisation. European Nephrology, 2011; 5(2):116-20

6. Siew ED, Recent advances in acute kidney injury epidemiology, Current Opin in Nephrol Hypertens. 2012 May; 21(3): 309-17. PMCID: PMC3357067

7. Fatima, H, Siew ED, Dwyer JP, Paukesakon, P. Clinical Report: Membranous Glomerulopathy with Superimposed Pauci-Immune Necrotizing Crescentic Glomerulonephritis. Clin Kidney J 5:587-590, 2012.

8. Siew ED, Himmelfarb J. The Inexorable Rise in Acute Kidney Injury – Can We Bend the Growth Curve? J Am Soc Nephrol. 2013 Jan; 24 (1):3-5. Epub 2012 Dec 14. No abstract available. PMCID: PMC3537222

9. McCullough PA, Shaw AD, Haase M, Bouchard J, Waikar SS, Siew ED, Murray PT, Mehta RL, Ronco C. Diagnosis of Acute Kidney Injury Using Functional and Injury Biomarkers: Workgroup Statements From the Tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib Nephrol. 2013 (182):13-29.

10. McCullough PA, Bouchard J, Waikar SS, Siew ED, Endre ZH, Goldstein SL, Koyner JL, Macedo E, Doi K, Di Somma S, Lewington A, Thadhani R, Chakravarthi R, Ice C, Okusa MD, Duranteau J, Doran P, Yang L, Jaber BL, Meehan S, Kellum JA, Haase M, Murray PT, Cruz D, Maisel A, Bagshaw SM, Chawla LS, Mehta RL, Shaw AD, Ronco C. Implementation of Novel Biomarkers in the Diagnosis, Prognosis, and Management of Acute Kidney Injury: Executive Summary from the Tenth Consensus Conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol 2013;(182):5-12.

Book Chapters:

1. Siew ED and J. Himmelfarb. Metabolic and Nutritional Complications of Acute Kidney Injury in Chronic Kidney Disease, Dialysis, and Transplantation, Third Edition

2. Parr, SK, Siew, ED. Acute Kidney Injury in Chronic Kidney Disease in Management of Chronic Kidney Disease (Book Chapter) (In Press)