Gautam (Jay) Bhave, M.D., Ph.D

Department and Division:
Dept. of Medicine, Division of Nephrology and Hypertension
Rank:
Assistant Professor
Office Address:
Vanderbilt University School of Medicine
1161 21st Avenue South
S-3223 Medical Center North
Nashville TN 37232-2372
Office Phone:
615-322-7305
Office Fax:
615-343-4704
Email:
gautam.Bhave@vanderbilt.edu
Undergraduate School & Degree:
Cornell University, BS.
Medical School & Degree:
Baylor College of Medicine, MD
Graduate School & Degree
Baylor College of Medicine, PhD

 

 

Research Focus:


Dr. Bhave is interested in the assembly and function of basement membranes and extracellular matrix particularly in renal disease. By studying matrix biochemistry at a fundamental level, I hope to gain insight into renal glomerular and tubulointerstitial fibrosis which represents the common final pathway to injury in nearly all kidney diseases. My group utilizes cell culture systems, molecular biology, biochemistry, mass spectrometry, and mouse genetics to answer questions of interest.

 

Dr. Bhave is also a member of the Vanderbilt.Center for Kidney Disease (VCKD)

For more information regarding VCKD, please click the link below.

http://www.vckd.org

Publications:


 

Bhave, G., Cummings, C.F., Vanacore, R.V., Kumagai-Cresse, C., Ero-Tolliver, I.A., Rafi, M., Kang, J.-S., Pedchenko, V.P., Fessler, L.I., Fessler, J.H., Hudson, B.G. (2012). Peroxidasin Forms Sulfilimine Chemical Bonds Using Hypohalous Acids In Tissue Genesis. Nature Chemical Biology 8: 784-790.

McCoy, A.B., Cox, Z.L., Neal, E.B., Waitman, L.R., Peterson, N.B., Bhave, G., Siew, E.D., Danciu, I., Lewis, J.B., Peterson, J.F. (2012). Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. Applied Clinical Informatics 3: 221-238.

Bhave, G.,  Chauder, B.A., Liu, W., Dawson, E.S., Kadakia, R., Nguyen, T.T., Lewis, L.M., Meiler, J., Weaver, C.D., Satlin, L.M., Lindsley, C.W., Denton, J.S. (2011). Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Molecular Pharmacology 79: 142-150.

Lewis, L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D., and Denton J.S. (2009). High Throughput Screening Reveals a Small Molecule Inhibitor of ROMK and Kir7.1. Molecular Pharmacology 76: 1094-1103.

Bhave, G., Hu, H.-J., Glauner, K.S., Zhu, W., Wang, H., Brasier, D.J., Oxford, G.S., and Gereau, R.W. (2003). Protein Kinase C Phosphorylation Sensitizes but Does Not Activate the Capsaicin Receptor, TRPV1. Proceedings of the National Academy of Sciences 100: 12480-12485.

Bhave, G., Nadin, B., Brasier, D.J., Glauner, K.S., Shah, R., Heinemann, S.F., Karim, F., and Gereau, R.W. (2003). Membrane Topology of a Metabotropic Glutamate Receptor. Journal of Biological Chemistry 278: 30294-30301

Neugebauer, V., Li, W., Bird, G.C., Bhave, G., and Gereau, R.W. (2003). Synaptic Plasticity in the Amygdala in Prolonged Pain: Differential Roles of mGluR1 and mGluR5. Journal of Neuroscience 23: 52-63.

Bhave, G., Zhu, W., Wang, H., Brasier, D.J., Oxford, G.S., and Gereau, R.W. (2002). cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation. Neuron 35: 721-731.

Hu, H.-J., Bhave, G., and Gereau, R.W. (2002). Prostaglandin and PKA-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia. Journal of Neuroscience 22: 7444-7452.

Bhave, G., Karim, F., Carlton, S.M., and Gereau, R.W. (2001). Peripheral Group I mGluRs Modulate Nociception in Mice. Nature Neuroscience 4: 417-423.