Zent, Roy , M.D., Ph.D.

Rank:
Professor of Medicine
Primary Department:
Dept. of Medicine
Secondary Department:
Cancer Biology and Cell and Developmental Biology
Division:
Nephrology and Hypertension
Office Address:
Vanderbilt University School of Medicine
1161 21st Avenue South
S-3223 Medical Center North
Nashville TN 37232-2372
Office Phone:
615-322-4632
Office Fax:
615-343-7156
Email:
roy.zent@vanderbilt.edu
Medical School & Degree:
M.D.University of Witwatersrand, Johannesburg, South Africa
Graduate School & Degree:
Ph.D. University of Toronto, Ontario, Canada
ABIM & Subspecialty:

Internal Medicine

Brief Bio:

Education: Bachelor of Medicine and Surgery (MBBcH), University of Witwatersrand 1978-1984;PhD University of Toronto 1993-1997.
Degrees and qualifications: 1993 Fellow of the Royal College of Physicians Canada (FRCPC);1992 Masters of Medicine (MMED), University of Cape Town; 1991 Fellow of the South African College of Physicians (FCP)

Expertise:

General Nephrology

Research Focus:

The laboratory works on the basic role of integrins in epithelial cell biology. We utilize the kidney as a model system and perform biochemical techniques, cell biology and transgenic mice to understand the basic mechanisms whereby integrin-ECM interactions modify cell function. In addition, in collaboration with Dr. Charles Sanders, we perform structural functions on integrins utilizing NMR.

Publications:

Cleghorn, WM, Branch, KM, Kook, S, Arnette, C, Bulus, N, Zent, R, Kaverina, I, Gurevich, EV, Weaver, AM, Gurevich, VV. Arrestins regulate cell spreading and motility via focal adhesion dynamics. Mol Biol Cell, 26(4), 622-35, 2015.

Gangadhariah, MH, Luther, JM, Garcia, V, Paueksakon, P, Zhang, MZ, Hayward, SW, Love, HD, Falck, JR, Manthati, VL, Imig, JD, Schwartzman, ML, Zent, R, Capdevila, JH, Pozzi, A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J Am Soc Nephrol, 26(3), 597-610, 2015.

Karak??se, E, Geiger, T, Flynn, K, Lorenz-Baath, K, Zent, R, Mann, M, F??ssler, R. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites. J Cell Sci, 128(5), 1023-33, 2015.

Keller, B, M??hlenkamp, M, Deuschle, E, Siegfried, A, M??ssner, S, Schade, J, Griesinger, T, Katava, N, Braunsdorf, C, Fehrenbacher, B, Jim??nez-Soto, LF, Schaller, M, Haas, R, Genth, H, Retta, SF, Meyer, H, B??ttcher, RT, Zent, R, Sch??tz, M, Autenrieth, IB, Bohn, E. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol, 17(8), 1179-204, 2015.

Neelisetty, S, Alford, C, Reynolds, K, Woodbury, L, Nlandu-Khodo, S, Yang, H, Fogo, AB, Hao, CM, Harris, RC, Zent, R, Gewin, L. Renal fibrosis is not reduced by blocking transforming growth factor-?? signaling in matrix-producing interstitial cells. Kidney Int, 88(3), 503-14, 2015.

Wang, H, Chen, X, Su, Y, Paueksakon, P, Hu, W, Zhang, MZ, Harris, RC, Blackwell, TS, Zent, R, Pozzi, A. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int, 87(5), 948-62, 2015.

Yazlovitskaya, EM, Tseng, HY, Viquez, O, Tu, T, Mernaugh, G, McKee, KK, Riggins, K, Quaranta, V, Pathak, A, Carter, BD, Yurchenco, P, Sonnenberg, A, B??ttcher, RT, Pozzi, A, Zent, R. Integrin ??3??1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell, 26(10), 1857-74, 2015.

Yi, Y, Polosukhina, D, Love, HD, Hembd, A, Pickup, M, Moses, HL, Lovvorn, HN, Zent, R, Clark, PE. A Murine Model of K-ras and ??-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J Urol, , , 2015.

Bryan, L, Ibrahim, T, Zent, R, Fischer, MJ. The kidney research predicament. J Am Soc Nephrol, 25(5), 898-903, 2014.

Byron, A, Randles, MJ, Humphries, JD, Mironov, A, Hamidi, H, Harris, S, Mathieson, PW, Saleem, MA, Satchell, SC, Zent, R, Humphries, MJ, Lennon, R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol, 25(5), 953-66, 2014.

Lennon, R, Byron, A, Humphries, JD, Randles, MJ, Carisey, A, Murphy, S, Knight, D, Brenchley, PE, Zent, R, Humphries, MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. J Am Soc Nephrol, 25(5), 939-51, 2014.

Miller, CG, Pozzi, A, Zent, R, Schwarzbauer, JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell, 25(16), 2342-50, 2014.

Plosa, EJ, Young, LR, Gulleman, PM, Polosukhin, VV, Zaynagetdinov, R, Benjamin, JT, Im, AM, van der Meer, R, Gleaves, LA, Bulus, N, Han, W, Prince, LS, Blackwell, TS, Zent, R. Epithelial ??1 integrin is required for lung branching morphogenesis and alveolarization. Development, 141(24), 4751-62, 2014.

Skrypnyk, N, Chen, X, Hu, W, Su, Y, Mont, S, Yang, S, Gangadhariah, M, Wei, S, Falck, JR, Jat, JL, Zent, R, Capdevila, JH, Pozzi, A. PPAR?? activation can help prevent and treat non-small cell lung cancer. Cancer Res, 74(2), 621-31, 2014.

Lee, K, Boyd, KL, Parekh, DV, Kehl-Fie, TE, Baldwin, HS, Brakebusch, C, Skaar, EP, Boothby, M, Zent, R. Cdc42 Promotes Host Defenses against Fatal Infection. Infect Immun, 81(8), 2714-23, 2013.

Moik, D, B??ttcher, A, Makhina, T, Grashoff, C, Bulus, N, Zent, R, F??ssler, R. Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice. J Biol Chem, 288(26), 18863-71, 2013.

Natarajan, C, Hata, AN, Hamm, HE, Zent, R, Breyer, RM. Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol Pharmacol, 83(1), 206-16, 2013.

Pozzi, A, Zent, R. Integrins in kidney disease. J Am Soc Nephrol, 24(7), 1034-9, 2013.

Bartlett, CS, Boyd, KL, Harris, RC, Zent, R, Breyer, RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension, 60(5), 1184-91, 2012.

Borza, CM, Su, Y, Chen, X, Yu, L, Mont, S, Chetyrkin, S, Voziyan, P, Hudson, BG, Billings, PC, Jo, H, Bennett, JS, Degrado, WF, Eckes, B, Zent, R, Pozzi, A. Inhibition of integrin I?2I?1 ameliorates glomerular injury. J Am Soc Nephrol, 23(6), 1027-38, 2012. PMCID:3386947

Borza, CM, Su, Y, Chen, X, Yu, L, Mont, S, Chetyrkin, S, Voziyan, P, Hudson, BG, Billings, PC, Jo, H, Bennett, JS, Degrado, WF, Eckes, B, Zent, R, Pozzi, A. Inhibition of integrin I?2I?1 ameliorates glomerular injury. J Am Soc Nephrol, 23(6), 1027-38, 2012. PMCID:3386947

Bulus, N, Feral, C, Pozzi, A, Zent, R. CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs. PLoS One, 7(6), e40026, 2012. PMCID:3386947

Gewin, L, Zent, R. How Does TGF-I? Mediate Tubulointerstitial Fibrosis. Semin Nephrol, 32(3), 228-35, 2012.

Lu, Z, Van Horn, WD, Chen, J, Mathew, S, Zent, R, Sanders, CR. Bicelles at low concentrations. Mol Pharm, 9(4), 752-61, 2012.

Pozzi, A, Zent, R. Hold tight or you''ll fall off: CD151 helps podocytes stick in high-pressure situations. J Clin Invest, 122(1), 13-6, 2012.

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin I?1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012.

Clark, PE, Polosukhina, D, Love, H, Correa, H, Coffin, C, Perlman, EJ, de Caestecker, M, Moses, HL, Zent, R. I?-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms'' tumors. Am J Pathol, 179(6), 3045-55, 2011.

Mathew, S, Chen, X, Pozzi, A, Zent, R. Integrins in renal development. Pediatr Nephrol, , , 2011.

Pozzi, A, Zent, R. Extracellular matrix receptors in branched organs. Curr Opin Cell Biol, , , 2011.

Pozzi, A, Zent, R. TGF-I? Sequestration by Mesangial Cell Integrin I?vI?8 A Novel Mechanism of Glomerular Endothelial Cell Regulation. Am J Pathol, 178(2), 485-9, 2011.

Borza, CM, Chen, X, Mathew, S, Mont, S, Sanders, CR, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem, 285(51), 40114-24, 2010.

Chen, X, Whiting, C, Borza, C, Hu, W, Mont, S, Bulus, N, Zhang, MZ, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol, 30(12), 3048-58, 2010.

Clark, PE, Polosukhina, DA, Gyabaah, K, Moses, HL, Thorburn, A, Zent, R. TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis. J Urol, 184(3), 1166-74, 2010.

Gewin, L, Bulus, N, Mernaugh, G, Moeckel, G, Harris, RC, Moses, HL, Pozzi, A, Zent, R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol, 21(8), 1334-43, 2010.

He, W, Wang, Y, Zhang, MZ, You, L, Davis, LS, Fan, H, Yang, HC, Fogo, AB, Zent, R, Harris, RC, Breyer, MD, Hao, CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest, 120(4), 1056-68, 2010. PMCID:2846063

Pozzi, A, Zent, R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med, 1(2), 254-72, 2010.

Pozzi, A, Zent, R. ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation. J Am Soc Nephrol, 21(3), 388-90, 2010. PMCID:2846063

Riggins, KS, Mernaugh, G, Su, Y, Quaranta, V, Koshikawa, N, Seiki, M, Pozzi, A, Zent, R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res, 316(17), 2993-3005, 2010.

Smeeton, J, Zhang, X, Bulus, N, Mernaugh, G, Lange, A, Karner, CM, Carroll, TJ, F??ssler, R, Pozzi, A, Rosenblum, ND, Zent, R. Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development, 137(19), 3233-43, 2010.

Wang, SE, Yu, Y, Criswell, TL, Debusk, LM, Lin, PC, Zent, R, Johnson, DH, Ren, X, Arteaga, CL. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene, , , 2010.

Yamashita, H, Tripathi, M, Harris, MP, Liu, S, Weidow, B, Zent, R, Quaranta, V. The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration. Biomaterials, 31(19), 5110-21, 2010.

Benjamin, JT, Gaston, DC, Halloran, BA, Schnapp, LM, Zent, R, Prince, LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol, 335(2), 407-17, 2009. PMCID:2846063

Cheng, H, Fan, X, Guan, Y, Moeckel, GW, Zent, R, Harris, RC. Distinct roles for basal and induced COX-2 in podocyte injury. J Am Soc Nephrol, 20(9), 1953-62, 2009. PMCID:2846063

Lange, A, Wickstr??m, SA, Jakobson, M, Zent, R, Sainio, K, F??ssler, R. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature, 461(7266), 1002-6, 2009. PMCID:2846063

Moser M, Legate KR, Zent R, Fassler R.. The tail of integrins, talin, and kindlins.. Science, 15(324), 895-9, 2009.

Moser, M, Legate, KR, Zent, R, F??ssler, R. The tail of integrins, talin, and kindlins. Science, 324(5929), 895-9, 2009. PMCID:2846063

Nystr??m, A, Shaik, ZP, Gullberg, D, Krieg, T, Eckes, B, Zent, R, Pozzi, A, Iozzo, RV. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood, 114(23), 4897-906, 2009. PMCID:2846063

Pozzi, A, Voziyan, PA, Hudson, BG, Zent, R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des, 15(12), 1318-33, 2009.

Pozzi, A, Zent, R, Chetyrkin, S, Borza, C, Bulus, N, Chuang, P, Chen, D, Hudson, B, Voziyan, P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J Am Soc Nephrol, 20(10), 2119-25, 2009. PMCID:2846063

Wang, SE, Xiang, B, Zent, R, Quaranta, V, Pozzi, A, Arteaga, CL. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res, 69(2), 475-82, 2009. PMCID:2629389

Zhang, X, Mernaugh, G, Yang, DH, Gewin, L, Srichai, MB, Harris, RC, Iturregui, JM, Nelson, RD, Kohan, DE, Abrahamson, D, F??ssler, R, Yurchenco, P, Pozzi, A, Zent, R. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development, 136(19), 3357-66, 2009. PMCID:2846063

Abair, TD, Bulus, N, Borza, C, Sundaramoorthy, M, Zent, R, Pozzi, A. Functional Analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood, , , 2008. PMCID:2569176

Abair, TD, Sundaramoorthy, M, Chen, D, Heino, J, Ivaska, J, Hudson, BG, Sanders, CR, Pozzi, A, Zent, R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res, 314(19), 3593-604, 2008. PMCID:2729514

Borza, CM, Borza, DB, Pedchenko, V, Saleem, MA, Mathieson, PW, Sado, Y, Hudson, HM, Pozzi, A, Saus, J, Abrahamson, DR, Zent, R, Hudson, BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol, 19(4), 677-84, 2008. PMCID:2390958

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008.

Macias-Perez, I, Borza, C, Chen, X, Yan, X, Ibanez, R, Mernaugh, G, Matrisian, LM, Zent, R, Pozzi, A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res, 68(15), 6127-35, 2008.

Macias-Perez, IM, Zent, R, Carmosino, M, Breyer, MD, Breyer, RM, Pozzi, A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem, 283(18), 12538-45, 2008. PMCID:2335350

Maginnis, MS, Mainou, BA, Derdowski, A, Johnson, EM, Zent, R, Dermody, TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol, 82(7), 3181-91, 2008. PMCID:2268482

Montanez, E, Ussar, S, Schifferer, M, B??sl, M, Zent, R, Moser, M, F??ssler, R. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev, 22(10), 1325-30, 2008. PMCID:2377186

Pozzi, A, Jarad, G, Moeckel, GW, Coffa, S, Zhang, X, Gewin, L, Eremina, V, Hudson, BG, Borza, DB, Harris, RC, Holzman, LB, Phillips, CL, Fassler, R, Quaggin, SE, Miner, JH, Zent, R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol, 316(2), 288-301, 2008. PMCID:2396524

Srichai, MB, Hao, C, Davis, L, Golovin, A, Zhao, M, Moeckel, G, Dunn, S, Bulus, N, Harris, RC, Zent, R, Breyer, MD. Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury. J Am Soc Nephrol, , , 2008. PMCID:2488270

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol, 27(9), 3313-26, 2007. PMCID:1899972

Dwyer, JP, Yates, KM, Sumner, EL, Stone, WJ, Wang, Y, Koury, MJ, Fogo, AB, Zent, R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin Nephrol, 67(3), 176-81, 2007.

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem, 282(38), 27713-20, 2007.

Rao, R, Redha, R, Macias-Perez, I, Su, Y, Hao, C, Zent, R, Breyer, MD, Pozzi, A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem, 282(23), 16959-68, 2007.

Voss, B, McLaughlin, JN, Holinstat, M, Zent, R, Hamm, HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol, 71(5), 1399-406, 2007.

Zeng, F, Zhang, MZ, Singh, AB, Zent, R, Harris, RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell, 18(11), 4446-56, 2007. PMCID:2043549

Zent, R, Pozzi, A. Angiogenesis in diabetic nephropathy. Semin Nephrol, 27(2), 161-71, 2007.

Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R. Integrin {alpha}3beta1, a Novel Receptor for {alpha}3(IV) Noncollagenous Domain and a Trans-dominant Inhibitor for Integrin {alpha}vbeta3. J Biol Chem, 281(30), 20932-9, 2006.

Liang, XB, Ma, LJ, Naito, T, Wang, Y, Madaio, M, Zent, R, Pozzi, A, Fogo, AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol, 17(7), 1886-95, 2006.

Moeckel, GW, Zhang, L, Chen, X, Rossini, M, Zent, R, Pozzi, A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am J Physiol Renal Physiol, 290(1), F223-31, 2006.

Nakagawa, K, Holla, VR, Wei, Y, Wang, WH, Gatica, A, Wei, S, Mei, S, Miller, CM, Cha, DR, Price, E, Zent, R, Pozzi, A, Breyer, MD, Guan, Y, Falck, JR, Waterman, MR, Capdevila, JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest, 116(6), 1696-702, 2006. PMCID:1459070

Pozzi, A, Coffa, S, Bulus, N, Zhu, W, Chen, D, Chen, X, Mernaugh, G, Su, Y, Cai, S, Singh, A, Brissova, M, Zent, R. H-Ras, R-Ras, and TC21 Differentially Regulate Ureteric Bud Cell Branching Morphogenesis. Mol Biol Cell, , , 2006. PMCID:1415315

Zent, R, Pozzi, A. Antiangiogenic therapy in diabetic nephropathy. J Am Soc Nephrol, 17(2), 325-7, 2006.

Zent, R, Yan, X, Su, Y, Hudson, BG, Borza, DB, Moeckel, GW, Qi, Z, Sado, Y, Breyer, MD, Voziyan, P, Pozzi, A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int, 70(3), 460-70, 2006.

Cai, S, Bulus, N, Fonseca-Siesser, PM, Chen, D, Hanks, SK, Pozzi, A, Zent, R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci, 118(Pt 5), 889-99, 2005.

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer, 116(1), 52-61, 2005.

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis, 22(2), 185-93, 2005.

Mai, W, Chen, D, Ding, T, Kim, I, Park, S, Cho, SY, Chu, JS, Liang, D, Wang, N, Wu, D, Li, S, Zhao, P, Zent, R, Wu, G. Inhibition of Pkhd1 Impairs Tubulomorphogenesis of Cultured IMCD Cells. Mol Biol Cell, , , 2005. PMCID:1196347

Mernaugh, RL, Yan, H, Chen, D, Edl, J, Hanley, G, Pozzi, A, Zent, R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J Immunol Methods, 306(1-2), 115-27, 2005.

Muraoka-Cook, RS, Shin, I, Yi, JY, Easterly, E, Barcellos-Hoff, MH, Yingling, JM, Zent, R, Arteaga, CL. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene, , , 2005.

Pozzi, A, Macias-Perez, I, Abair, T, Wey, S, Su, Y, Zent, R, Falk, JR, Capdevila, JH. Charaterization of 5,6-and 8,9-Epoxyeicosatrienoic acids (5,6- AND 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem, , , 2005.

Tvorogov, D, Wang, XJ, Zent, R, Carpenter, G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci, 118(Pt 3), 601-10, 2005.

Chen, Dong, Roberts, Richard, Pohl, Martin, Nigam, Sanjay, Kreidberg, Jordan, Wang, Zemin, Heino, Jyrki, Ivaska, Johanna, Coffa, Sergio, Harris, Raymond C., Pozzi, Ambra, Zent, Roy. Differential expression of collagen and laminin binding integrins mediate ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, , , 2004.

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004. PMCID:1618576

Fisher, ME, Rossini, M, Simmons, E, Harris, RC, Moeckel, G, Zent, R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am J Kidney Dis, 44(3), 567-73, 2004.

Henderson, NC, Collis, EA, Mackinnon, AC, Simpson, KJ, Haslett, C, Zent, R, Ginsberg, M, Sethi, T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem, 279(52), 54731-41, 2004.

Pedchenko, Vadim, Zent, Roy, Hudson, Billy G.. {alpha}v{beta}3 and {alpha}v{beta}5 Integrins Bind Both the Proximal RGD Site and Non-RGD Motifs within Noncollagenous (NC1) Domain of the {alpha}3 Chain of Type IV Collagen: IMPLICATION FOR THE MECHANISM OF ENDOTHELIAL CELL ADHESION. J Biol Chem, 279(4), 2772-2780, 2004.

Singh, Amar B, Tsukada, Toshiaki, Zent, Roy, Harris, Raymond C. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci, 117(Pt 8), 1365-79, 2004.

Hata, Aaron N, Zent, Roy, Breyer, Matthew D, Breyer, Richard M. Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther, 306(2), 463-70, 2003.

Koshikawa, Naohiko, Schenk, Susann, Moeckel, Gilbert, Sharabi, Andrew, Miyazaki, Kaoru, Gardner, Humphrey, Zent, Roy, Quaranta, Vito. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J, , , 2003.

Pozzi, Ambra, Zent, Roy. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol, 94(3), e77-84, 2003.

Bhowmick, N A, Zent, R, Ghiassi, M, McDonnell, M, Moses, H L. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem, 276(50), 46707-13, 2001.

Fenczik, C A, Zent, R, Dellos, M, Calderwood, D A, Satriano, J, Kelly, C, Ginsberg, M H. Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem, 276(12), 8746-52, 2001.

Zent, R, Bush, K T, Pohl, M L, Quaranta, V, Koshikawa, N, Wang, Z, Kreidberg, J A, Sakurai, H, Stuart, R O, Nig?!m, S K. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol, 238(2), 289-302, 2001.

Zent, R, Fenczik, C A, Calderwood, D A, Liu, S, Dellos, M, Ginsberg, M H. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J Biol Chem, 275(7), 5059-64, 2000.

Calderwood, D A, Zent, R, Grant, R, Rees, D J, Hynes, R O, Ginsberg, M H. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem, 274(40), 28071-4, 1999.

Zent, R, Ailenberg, M, Downey, G P, Silverman, M. ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling. Am J Physiol, 276(2 Pt 2), F278-87, 1999.

Zent, R, Ailenberg, M, Silverman, M. Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: response to fetal bovine serum and platelet-derived growth factor-BB. Exp Cell Res, 240(1), 134-43, 1998.

Zent, R, Katz, A, Quaggin, S, Cattran, D, Wade, J, Cardella, C, Zaltzman, J, Fenton, S, Cole, E. Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clin Nephrol, 47(3), 181-6, 1997.

Zent, R, Nagai, R, Cattran, D C. Idiopathic membranous nephropathy in the elderly: a comparative study. Am J Kidney Dis, 29(2), 200-6, 1997.

De Villiers, C, Zent, R, Eastman, R W, Swingler, D. A flight of fantasy: false memories in frontal lobe disease. J Neurol Neurosurg Psychiatry, 61(6), 652-3, 1996. PMCID:486667

Zent, R, Ailenberg, M, Waddell, T K, Downey, G P, Silverman, M. Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species. Kidney Int, 47(3), 811-7, 1995.

Bargman, J M, Zent, R, Ellis, P, Auger, M, Wilson, S. Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology. Am J Kidney Dis, 23(5), 747-50, 1994.

Katz, A, Zent, R, Bargman, J M. IgG heavy-chain deposition disease. Mod Pathol, 7(8), 874-8, 1994.

Zent, R, Myers, J E, Donald, D, Rayner, B L. Continuous ambulatory peritoneal dialysis: an option in the developing world. Perit Dial Int, 14(1), 48-51, 1994.

Zent, R, Van Zyl Smit, R, Duffield, M, Cassidy, M J. Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign disease. Clin Nephrol, 42(1), 22-9, 1994.

Morton, L P, Reynolds, L, Zent, R, Rayner, B L. Hearing thresholds in CAPD patients. Adv Perit Dial, 8, 150-2, 1992.