Christopher N. Johnson, Ph.D.

Research Instructor in Medicine


Division

Clinical Pharmacology

Education:

Ph.D. - Georgia State University

M.S., Biochemistry, Georgia State University, Atlanta, Georgia

B.S., Chemistry, State University of New York, Fredonia, New York

Dr. Johnson is a structural biologist that utilizes a multi-disciplinary approach to understand calcium regulatory processes in the heart. His work combines structural biology, biophysics and electrophysiology in order to understand how the intra-cellular calcium sensing protein “Calmodulin" transduces changes in calcium concentration into protein-protein interactions, and how these events influence or regulate the cardiac excitation contraction cycle. In recognition of his achievements, Dr. Johnson has received both an NRSA F32 fellowship and an American Heart Association postdoctoral fellowship during his previous postdoctoral training at Vanderbilt. Dr. Johnson has also received numerous awards from scientific societies, including a recent poster award at the 2016 World Congress of the International Society for Heart Research, and a Young Investigator Award at the 2016 European Muscle Society Meeting. Dr. Johnson joined the Vanderbilt Faculty as a Research Instructor in Medicine in the Summer of 2016.


Office Address:
536 RRB, Nashville, TN

Christopher N. Johnson, Ph.D.

Phone No. 

615-936-2233

Previous Institution 

Vanderbilt University Medical Center

Previous Role/Title 

Research Fellow

Specialty 

Cardiac sodium channel function

Hometown 

Buffalo, NY

publications 

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and SparksCirc Arrhythm Electrophysiol. 2016 Aug; 9(8): PMID: 27516456, PMCID: PMC4988333, PII: CIRCEP.116.004161, DOI: 10.1161/CIRCEP.116.004161, ISSN: 1941-3084. 

Pipilas DC, Johnson CN, Webster G, Schlaepfer J, Fellmann F, Sekarski N, Wren LM, Ogorodnik KV, Chazin DM, Chazin WJ, Crotti L, Bhuiyan ZA, George AL. Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytesHeart Rhythm [print-electronic]. 2016 Jul 7/1/2016; PMID: 27374306, PII: S1547-5271(16)30499-4, DOI: 10.1016/j.hrthm.2016.06.038, ISSN: 1556-3871. 

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL, Cornea RL, Bers DM, Knollmann BC.Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutantsCirc. Res [print-electronic]. 2014 Mar 3/28/2014; 114(7): 1114-24. PMID: 24563457, PMCID: PMC3990285, PII: CIRCRESAHA.114.303391, DOI: 10.1161/CIRCRESAHA.114.303391, ISSN: 1524-4571. 

Raikwar HP, Muthian G, Rajasingh J, Johnson CN, Bright JJ. PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2J. Neuroimmunol [print-electronic]. 2006 Sep; 178(1-2): 76-86. PMID: 16844232, PII: S0165-5728(06)00194-9, DOI: 10.1016/j.jneuroim.2006.05.013, ISSN: 0165-5728.