Jonathan D. Mosley, M.D., Ph.D.

Assistant Professor of Medicine , Department of Medicine

Division of Clinical Pharmacology, Vanderbilt University


Division

Clinical Pharmacology

Education:

M.D., Case Western Reserve University, Cleveland, Ohio

Ph.D., PHARMACOLOGY, Case Western Reserve University, Cleveland, Ohio

.S., Dickinson College, Carlisle, Pennsylvania

Dr. Jonathan Mosley is a clinically trained scientist with a professional background in mathematics, information systems development, and epidemiology, with doctoral training in molecular and mouse models of mammary gland tumorigenesis. His research focus is on developing approaches to utilize Vanderbilt’s integrated electronic medical record and DNA biobank to delineate risk factors that predispose an individual to disease susceptibility. In this context, he has worked on pharmacogenomics projects looking at adverse drug reactions and association studies linking genetic variation to human morbidity. His particular interest is related to re-organizing clinical disease taxonomies to better reflect the underlying molecular and genetic risk factors driving the pathological processes.These mechanism-oriented taxonomies would increase diagnostic specificity, guide the development and use of targeted therapies, and enhance targeted healthcare delivery strategies. Dr. Mosley's current research efforts involve the application of generalized linear mixed models approaches to delineate the etiological relationships among clinical phenotypes.


Office Address:
1215B Garland Ave, Nashville, TN

Jonathan D. Mosley, M.D., Ph.D.

Phone No. 

615-322-2959

Previous Institution 

Case Western Reserve University

Previous Role/Title 

Clinical Fellow, Division of Clinical Pharmacology

Specialty 

Internal Medicine

Hometown 

Baltimore, MD

publications 

Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced coughPharmacogenomics J [print-electronic]. 2016 Jun; 16(3): 231-7. PMID: 26169577, PMCID: PMC4713364, PII: tpj201551, DOI: 10.1038/tpj.2015.51, ISSN: 1473-1150. 

Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Identifying genetically driven clinical phenotypes using linear mixed modelsNat Commun. 2016; 7: 11433. PMID: 27109359, PMCID: PMC4848547, PII: ncomms11433, DOI: 10.1038/ncomms11433, ISSN: 2041-1723. 

Mosley JD, Brittain EL, Loyd JE, Denny JC, Austin ED, Larkin EK. Letter by Mosley Regarding Article, "Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat" [letter]Circ. Res. 2015 Aug 8/28/2015; 117(6): e56-7. PMID: 26316607, PMCID: PMC4557206, PII: CIRCRESAHA.115.306867, DOI: 10.1161/CIRCRESAHA.115.306867, ISSN: 1524-4571. 

Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical recordThromb. Haemost [print-electronic]. 2015 Apr; 113(4): 772-81. PMID: 25503805, PMCID: PMC4433536, PII: 14-08-0670, DOI: 10.1160/TH14-08-0670, ISSN: 0340-6245. 

Weeke P, Muhammad R, Delaney JT, Shaffer C, Mosley JD, Blair M, Short L, Stubblefield T, Roden DM, Darbar D, . Whole-exome sequencing in familial atrial fibrillationEur. Heart J [print-electronic]. 2014 Sep 9/21/2014; 35(36): 2477-83. PMID: 24727801, PMCID: PMC4169871, PII: ehu156, DOI: 10.1093/eurheartj/ehu156, ISSN: 1522-9645. 

Yori JL, Lozada KL, Seachrist DD, Mosley JD, Abdul-Karim FW, Booth CN, Flask CA, Keri RA. Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regressionCancer Res [print-electronic]. 2014 Sep 9/1/2014; 74(17): 4762-71. PMID: 25023728, PMCID: PMC4155007, PII: 0008-5472.CAN-13-3627, DOI: 10.1158/0008-5472.CAN-13-3627, ISSN: 1538-7445. 

Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metforminClin. Pharmacol. Ther [print-electronic]. 2014 Sep; 96(3): 370-9. PMID: 24853734, PMCID: PMC4171106, PII: clpt2014109, DOI: 10.1038/clpt.2014.109, ISSN: 1532-6535. 

Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium currentCirculation [print-electronic]. 2014 Jul 7/15/2014; 130(3): 224-34. PMID: 24895457, PMCID: PMC4101031, PII: CIRCULATIONAHA.113.007765, DOI: 10.1161/CIRCULATIONAHA.113.007765, ISSN: 1524-4539. 

Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM. Biobanks and electronic medical records: enabling cost-effective researchSci Transl Med. 2014 Apr 4/30/2014; 6(234): 234cm3. PMID: 24786321, PMCID: PMC4226414, PII: 6/234/234cm3, DOI: 10.1126/scitranslmed.3008604, ISSN: 1946-6242. 

Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndromeJ. Am. Coll. Cardiol [print-electronic]. 2014 Apr 4/15/2014; 63(14): 1430-7. PMID: 24561134, PMCID: PMC4018823, PII: S0735-1097(14)00446-X, DOI: 10.1016/j.jacc.2014.01.031, ISSN: 1558-3597. 

Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM. Using systems approaches to address challenges for clinical implementation of pharmacogenomicsWiley Interdiscip Rev Syst Biol Med [print-electronic]. 2014 Mar; 6(2): 125-35. PMID: 24319008, PMCID: PMC3944797, DOI: 10.1002/wsbm.1255, ISSN: 1939-005X. 

Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass indexFront Genet. 2014; 5: 250. PMID: 25177340, PMCID: PMC4134007, DOI: 10.3389/fgene.2014.00250, ISSN: 1664-8021. 

Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC. Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associationsPLoS ONE. 2014; 9(6): e100322. PMID: 24949630, PMCID: PMC4065041, PII: PONE-D-14-03337, DOI: 10.1371/journal.pone.0100322, ISSN: 1932-6203. 

Weeke P, Delaney J, Mosley JD, Wells Q, Van Driest S, Norris K, Kucera G, Stubblefield T, Roden DM. QT variability during initial exposure to sotalol: experience based on a large electronic medical recordEuropace [print-electronic]. 2013 Dec; 15(12): 1791-7. PMID: 23787903, PMCID: PMC3888125, PII: eut153, DOI: 10.1093/europace/eut153, ISSN: 1532-2092. 

Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathyCirc Cardiovasc Genet [print-electronic]. 2013 Aug; 6(4): 317-26. PMID: 23861363, PMCID: PMC3895490, PII: CIRCGENETICS.113.000011, DOI: 10.1161/CIRCGENETICS.113.000011, ISSN: 1942-3268. 

Wei WQ, Mosley JD, Bastarache L, Denny JC. Validation and enhancement of a computable medication indication resource (MEDI) using a large practice-based datasetAMIA Annu Symp Proc. 2013; 2013: 1448-56. PMID: 24551419, PMCID: PMC3900157, ISSN: 1942-597X. 

Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS dataPLoS ONE. 2013; 8(12): e81503. PMID: 24349080, PMCID: PMC3861317, PII: PONE-D-13-29989, DOI: 10.1371/journal.pone.0081503, ISSN: 1932-6203.