Postdoctoral Trainee, Department of Medicine, Division of Geriatric Medicine
1161 21st Avenue South, Medical Center North, Nashville, TN 37232
Bradley Kraemer, Ph.D., joined the program in 2015 under the mentorship of Laura Dugan, MD, Director of the Division of Geriatric Medicine. Bradley is interested in the effects of oxidative stress and inflammation on neurodegeneration and cognitive decline, the recently reported serious and costly complications of sepsis in early life (neonates) and late life (elderly). One important subset of cells within the brain that is particularly vulnerable to these effects is the population of parvalbumin-expressing interneurons (PV-interneurons) of the cortex and hippocampus. Dr. Dugan’s lab previously demonstrated that these neurons undergo a dramatic loss of phenotype in response to pleiotropic inflammatory cytokine IL-6 or following activation of superoxide production by NADPH-oxidase-2 (NOX2). Current studies are aimed at determining the cell-specific interactions and downstream signaling cascades responsible for this loss of phenotype. Utilizing several genetic mouse models with conditional deletion of the IL-6 effector, STAT3, Bradley is currently investigating the role of STAT3 signaling in the inflammation-associated loss of PV interneuron phenotype. Additionally, recent work has demonstrated that NOX2 is substantially downregulated by the age-suppressor protein klotho. Current studies are evaluating the potential neuroprotective effects of klotho on maintenance of PV-interneuron phenotype.