David M. Aronoff, M.D.

Director, Division of Infectious Diseases

Addison B. Scoville Jr. Chair in Medicine

Professor of Medicine


Infectious Diseases


M.D. - Tufts University

B.S. - Indiana University, Bloomington, IN 1987-1991

B.S. - University of Kent, United Kingdom 1989-1990



Vanderbilt University School of Medicine, Nashville, TN 1998- 2002 University of Michigan, Ann Arbor, Michigan 2002-2004


Vanderbilt University School of Medicine, Nashville, TN 1995-1996

Office Address:
1161 21st Avenue South, Medical Center North, Nashville, TN, TN 37232-2582

David M. Aronoff, M.D.

Research Focus:

Research Description 

The overarching goal of the Aronoff lab is to improve human health through discovery, with a primary interest on maternal-child wellness. The Aronoff lab studies reproductive immunology with a focus on bacterial infections that complicate pregnancy. These infections include perinatal streptococcal infections and postpartum clostridial infections. Our major interest is revealing root molecular mechanisms whereby bacterial pathogens evade innate immunity within the female reproductive tract. We also study the impact of metabolic stressors such as obesity and diabetes on reproductive immunology and placental function. Our work with toxigenic clostridia has extended to non-reproductive tract infections, such as colitis caused by Clostridium diffficile. Members of our lab engage in a range of research approaches, from purely bench science to translational science to purely clinical research. We value interdisciplinary team science.

Honors and Awards 

Dean’s List, Indiana University (8 consecutive semesters) 1987-1991

Alpha Lambda Delta Freshman Honor Society 1988

Phi Eta Sigma Freshman Honor Society 1988

Phi Beta Kappa Honor Society 1991

Honors Division Senior Achievement Award 1991

L.S. McClung Scholar in Microbiology (Indiana University) 1991

Alpha Omega Alpha (Early Admission Junior Year; Tufts University) 1994         

Louis Weinstein Prize (Tufts University Medical School) 1995     

Tufts Alumni Association Scholar 1995     

Housestaff Clinical Teaching Award (Vanderbilt University) 2000          

BIOMOL Young Investigator Award 2001           

GlaxoSmithKline HIV Fellow 2001

Infectious Diseases Fellow Teaching Award (Vanderbilt University) 2002          

Basic Research Citation, Dept. of Internal Medicine (Vanderbilt Univ.) 2002    

Cayman Chemical Company Travel Award 2003 

Parker B. Francis Fellowship in Pulmonary Research 2004         

NIH Extramural Clinical Research Loan Repayment Program 2004    

Top 10 research abstract, Department of Internal Medicine Research Symposium (University of Michigan) 2005                                       

Program Committee Choice Award, Infectious Diseases Society of America 2005         

NIH Extramural Clinical Research Loan Repayment Program 2005    

UMHHC Employee Recognition Program Award (x2) 2006       

NIH Extramural Clinical Research Loan Repayment Program (competitive renewal) 2006

Burroughs Wellcome Fund Investigators in Pathogenesis of Infectious Disease Award Finalist (top 25) 2007

UMHHC Employee Recognition Program Award 2007

Doris Duke Charitable Foundation Clinical Scientist Development Award 2007

Research featured in the University of Michigan Dept. of Internal Medicine Annual Report 2007

Burroughs Wellcome Fund Investigators in Pathogenesis of Infectious Disease Award Finalist (top 25) 2008

Central Society for Clinical Research (CSCREarly Career Development Award 2008

CSCR K Award Grant 2008

“You’re Super” UMHHC Employee Recognition Program Award 2008

NIH Extramural Clinical Research Loan Repayment Program (competitive renewal) 2008

NIEHS Young Investigator Travel Award, 11th International Winter Eicosanoid Conference 2009

Poster Presentation Award, 11th International Winter Eicosanoid Conference 2009

Featured in the University of Michigan Undergraduate Research Journal online (http://umurj.org/Interviews/interviews/63-david-aronoff-interview) 2009

Featured as an NIH Loan Repayment Program Success Story 2009

Burroughs Wellcome Fund Investigators in Pathogenesis of Infectious Disease Award Awardee (1 of 10) 2011

American Society for Clinical Investigation 2013

Phone No. 

(615) 322-2035

Research Keywords 

Reproductive health, DOHaD (Developmental Origins of Health and Disease), aerobic and anaerobic bacterial pathogenesis, and innate immunity


Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA. Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity. Front Cell Infect Microbiol. 2017; 7: 19. PMID: 28217556, PMCID: PMC5289994, DOI: 10.3389/fcimb.2017.00019, ISSN: 2235-2988. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28217556., 2017.

Anders AP, Gaddy JA, Doster RS, Aronoff DM. Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells. Am. J. Reprod. Immunol [print-electronic]. 2017 Mar; 77(3): PMID: 28044385, PMCID: PMC5321847, DOI: 10.1111/aji.12623, ISSN: 1600-0897. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28044385., 2017.

Prioreschi A, Munthali RJ, Soepnel L, Goldstein JA, Micklesfield LK, Aronoff DM, Norris SA. Incidence and prevalence of type 2 diabetes mellitus with HIV infection in Africa: a systematic review and meta-analysis. BMJ Open. 2017 Mar 3/29/2017; 7(3): e013953. PMID: 28360243, PMCID: PMC5372101, PII: bmjopen-2016-013953, DOI: 10.1136/bmjopen-2016-013953, ISSN: 2044-6055. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28360243., 2017.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay Drug Dev Technol [print-electronic]. 2017 Apr; 15(3): 113-9. PMID: 28379727, PMCID: PMC5399743, DOI: 10.1089/adt.2016.772, ISSN: 1557-8127. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28379727., 2017.

Goldstein JA, Norris SA, Aronoff DM. DOHaD at the intersection of maternal immune activation and maternal metabolic stress: a scoping review. J Dev Orig Health Dis [print-electronic]. 2017 Jun; 8(3): 273-83. PMID: 28196555, PII: S2040174417000010, DOI: 10.1017/S2040174417000010, ISSN: 2040-1752. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28196555., 2017.

Ackerman DL, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD. Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus. ACS Infect Dis [print-electronic]. 2017 Jun 6/13/2017; PMID: 28570820, DOI: 10.1021/acsinfecdis.7b00064, ISSN: 2373-8227. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28570820., 2017.

Carson WF, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL. The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages. J. Immunol [print-electronic]. 2017 Jul 7/21/2017; PMID: 28733487, PII: jimmunol.1601272, DOI: 10.4049/jimmunol.1601272, ISSN: 1550-6606. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28733487., 2017.

Aronoff DM, Correa H, Rogers LM, Arav-Boger R, Alcendor DJ. Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease. Am. J. Reprod. Immunol [print-electronic]. 2017 Sep; 78(3): PMID: 28741727, PMCID: PMC5561471, DOI: 10.1111/aji.12728, ISSN: 1600-0897. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28741727., 2017.

Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE. Prostaglandin E2 Regulation of Macrophage Innate Immunity. Chem. Res. Toxicol [print-electronic]. 2016 Jan 1/19/2016; 29(1): 19-25. PMID: 26656203, DOI: 10.1021/acs.chemrestox.5b00322, ISSN: 1520-5010. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26656203., 2016.

Rogers MA, Aronoff DM. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin. Microbiol. Infect [print-electronic]. 2016 Feb; 22(2): 178.e1-9. PMID: 26482265, PMCID: PMC4754147, PII: S1198-743X(15)00902-7, DOI: 10.1016/j.cmi.2015.10.003, ISSN: 1469-0691. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26482265., 2016.

Singh P, Aronoff DM, Davies HD, Manning SD. Draft Genome Sequence of an Invasive Streptococcus agalactiae Isolate Lacking Pigmentation. Genome Announc. 2016 Feb 2/25/2016; 4(1): PMID: 26950320, PMCID: PMC4767910, PII: 4/1/e00015-16, DOI: 10.1128/genomeA.00015-16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26950320., 2016.

Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Jun 6/1/2016; 310(11): L1111-20. PMID: 27059285, PMCID: PMC4935474, PII: ajplung.00220.2015, DOI: 10.1152/ajplung.00220.2015, ISSN: 1522-1504. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27059285., 2016.

Doster RS, Kirk LA, Tetz LM, Rogers LM, Aronoff DM, Gaddy JA. Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines. J. Infect. Dis [print-electronic]. 2016 Jul 7/19/2016; PMID: 27436434, PII: jiw300, DOI: 10.1093/infdis/jiw300, ISSN: 1537-6613. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27436434., 2016.

Korir ML, Laut C, Rogers LM, Plemmons JA, Aronoff DM, Manning SD. Differing mechanisms of surviving phagosomal stress among group B Streptococcus strains of varying genotypes. Virulence [print-electronic]. 2016 Oct 10/28/2016; 1-14. PMID: 27791478, DOI: 10.1080/21505594.2016.1252016, ISSN: 2150-5608. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27791478., 2016.

Kalams SA, Rogers LM, Smith RM, Barnett L, Crumbo K, Sumner S, Prashad N, Rybczyk K, Milne G, Dowd SE, Chong E, Winikoff B, Aronoff DM. Neither vaginal nor buccal administration of 800¿µg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study. Eur J Contracept Reprod Health Care [print-electronic]. 2016 Dec; 21(6): 436-42. PMID: 27636701, DOI: 10.1080/13625187.2016.1229765, ISSN: 1473-0782. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27636701., 2016.

Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM. Lipid profiling of polarized human monocyte-derived macrophages. Prostaglandins Other Lipid Mediat [print-electronic]. 2016 Dec; 127: 1-8. PMID: 27871801, PII: S1098-8823(16)30108-3, DOI: 10.1016/j.prostaglandins.2016.11.002, ISSN: 1098-8823. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27871801., 2016.

Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PLoS ONE. 2015; 10(4): e0124235. PMID: 25885671, PMCID: PMC4401762, PII: PONE-D-14-44970, DOI: 10.1371/journal.pone.0124235, ISSN: 1932-6203. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25885671., 2015.

Natarajan M, Rogers MA, Bundy J, Micic D, Walk ST, Santhosh K, Rao K, Winters S, Young VB, Aronoff DM. Gender Differences in Non-Toxigenic Clostridium difficile Colonization and Risk of Subsequent C. difficile Infection. Clin Res Infect Dis [print-electronic]. 2015; 2(2): PMID: 28713874. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28713874., 2015.

Abdelsattar ZM, Krapohl G, Alrahmani L, Banerjee M, Krell RW, Wong SL, Campbell DA, Aronoff DM, Hendren S. Postoperative burden of hospital-acquired Clostridium difficile infection. Infect Control Hosp Epidemiol. 2015 Jan; 36(1): 40-6. PMID: 25627760, PMCID: PMC4597881, PII: S0899823X14000087, DOI: 10.1017/ice.2014.8, ISSN: 1559-6834. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25627760., 2015.

Boldenow E, Hogan KA, Chames MC, Aronoff DM, Xi C, Loch-Caruso R. Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am. J. Reprod. Immunol [print-electronic]. 2015 Mar; 73(3): 263-72. PMID: 25263616, PMCID: PMC4323989, DOI: 10.1111/aji.12325, ISSN: 1600-0897. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25263616., 2015.

Kopliku FA, Schubert AM, Mogle J, Schloss PD, Young VB, Aronoff DM. Low prevalence of Clostridium septicum fecal carriage in an adult population. Anaerobe [print-electronic]. 2015 Apr; 32: 34-6. PMID: 25481351, PMCID: PMC4385462, PII: S1075-9964(14)00175-9, DOI: 10.1016/j.anaerobe.2014.12.001, ISSN: 1095-8274. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25481351., 2015.

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Vanderbilt University School of Medicine, Nashville, TN 1998- 2002 University of Michigan, Ann Arbor, Michigan 2002-2004


Vanderbilt University School of Medicine, Nashville, TN 1996- 1998