Research During Residency

Performing scholarly work is an essential component of the Vanderbilt residency training experience. Vanderbilt provides residents with a wide array of opportunities to participate in clinical investigations, translational research, basic science research, health services research, and research in educational methods. Program leadership is committed to enabling each resident to take advantage of these resources. Early in the internship year, each intern meets individually with program leadership to discuss specific interests. Following this discussion and as individual career plans begin to crystalize, each intern is assigned to one or more mentors. These mentors play many roles: career counselor, personal advisor, friendly sounding board, and for many of our residents, research advisor. Individual meetings with program leadership continue on a regular basis throughout residency to ensure that each resident connects with faculty that share common scholarly interests.

BioVU and the Synthetic Derivative

Leveraging its expertise in medical informatics, Vanderbilt has two unique resources for discovery: BioVU and the Synthetic Derivative. Many Department of Medicine faculty and residents are currently involved in funded projects using these programs.

BioVU is the Vanderbilt repository of DNA extracted from discarded blood collected during routine clinical testing and linked to de-identified clinical data in the Synthetic Derivative. DNA samples and re-deposited genetic data (GWAS, targeted genotyping, sequencing, etc.) within BioVU can be matched with de-identified clinical and demographic data within the Synthetic Derivative creating a centralized resource for making associations between genetic information and disease susceptibility or variable drug responses across populations. Currently, nearly 200,000 samples have been collected and continue to be collected at the rate of 1,000 per week.

The Synthetic Derivative is a database containing clinical information derived from Vanderbilt's electronic medical record, labeled with a unique research ID, and stripped of all personal identifiers. Thus, the Synthetic Derivative is a set of records that is no longer linked to the identified medical record from which it is derived. Currently, over two million records are contained in the Synthetic Derivative. The Synthetic Derivative can be used as a stand-alone research resource or can be used in conjunction with BioVU to identify record sets for genome-phenome analysis.

Clinical Investigator Toolbox

In the fall of 2012, a new two-week elective was created for second-year residents interested in learning more about and potentially pursuing a career that includes clinical investigation. The course is agnostic to specialties, as excellent clinical investigation can occur across the spectrum of medical specialties. Vanderbilt University has been a leader in clinical research dating back over 50 years. Residents are introduced to different aspects of clinical research, including clinical trial design, epidemiology, outcomes research, biostatistics, biomedical ethics, and human subject protection (IRB). The course addresses issues particular to writing medical abstracts and giving medical presentations. There is some time for independent study that can be used to work on an ongoing project or to help to find the mentorship needed to embark on a project. Representatives from the Masters of Science in Clinical Investigation (MSCI) and Masters of Public Health (MPH) provide an overview of their programs so that residents can determine if these advanced degrees would be of value to their career development. Given the short duration, this course is not designed to be comprehensive. Rather, it is designed to “whet the appetite” of the resident for clinical research.

Research Curriculum Rotation

In addition to the Clinical Investigator Toolbox elective, a new research rotation was established in 2013 that is available to all residents and is offered throughout the year. Residents enter into this rotation with a pre-identified research mentor with whom they work closely. The rotation also has a focused didactic curriculum covering important areas such as identifying a mentor, forming a question, literature review, defining methods, data collection, data analysis, and writing and presenting data. The balance of the rotation consists of protected time for residents to work on their projects.

Resident Publications and Presentations

Listed below are representative publications and presentations from current Vanderbilt residents and 2013 graduates on work performed during their residency; note that this list is not comprehensive.

All Residents Projects

2014 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Arinze, SadeInvestigated enrolment trends in a comprehensive HIV programme in rural north-central Nigeria.Manuscript PublishedDr. Muktar Aliyu
Halliday, SteveIs degree of response to vasodilator challenge predictive of survival in PAH?Manuscript PublishedAnna Hemnes
Pilarski, PiotrThe Vanderbilt Inpatient Cohort Study (VICS): major prospective cohort study examining the social determinants of readmission risk and death after a hospitalization for heart failure and myocardial infarctionIn ProgressSunil Kripalani, Eduard Vasilevskis

2015 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Alexander, MattAre there genetic differences in functional SNPs for IL-17/IL-23 or other inflammatory factors that associate with the development of hypertension in patients with rhuematoid arthritis?In ProgressQuinn Wells
Ballinger, TarahCurrent HER2 Testing Recommendations and Clinical Relevance as a Predictor of Response to Targeted TherapyManuscript PublishedVandana Abramson
How we manage JAK inhibition in allogeneic transplantation for myelofibrosisManuscript PublishedBipin Savani
Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPshot profilingManuscript PublishedVandana Abramson
bib4VUMC15, blydensa
Borges, Nyal
Byram, KevinDoes exercise affect CV risk factors in RA patients?In ProgressMichelle Ormseth
Can we develop a case definition in the Synthetic Derviative for GPA?In ProgressNarender Annapureddy
Claar, DruWe are using PheWAS to define the spectrum of clinical disease associated with SNPs that have been implicated in IPF through GWAS studies. We hope that identifying other disease processes that these SNPs are associated with will help to better understand the role of these genetic variants in IPF.Abstract AcceptedJon Kropski
Ergen, WilliamBowel Preparation Quality ImprovementManuscript SubmittedKeith Obstein
Feussner, DerekAlbumin dose in patients with cirrhosis who present with AKI and its effect on renal recoveryManuscript SubmittedAndrew Scanga
Iams, WadeDoes KRAS mutation status predict response to cytotoxic chemotherapy in patients with metastatic non-small cell lung cancer?Poster PresentedChristine Lovly, Leora Horn
Does NRAS mutation status predict response to immunotherapy in patients with metastatic melanoma?Manuscript PublishedChristine Lovly
What is the mechanism of lenalidomide-induced thyroid dysfunction in patients with diffuse large B cell lymphoma?Manuscript PublishedNishitha Reddy
Kiser, Stephanie
McPherson, John
Patel, NeelWill antibacterial envelope ls prevent CIED infection?Manuscript SubmittedDr. Christopher Ellis
Correlation between OSA and AfibIn ProgressDr. Ken Monahan
Patel , DevinRisk stratification of cvd with coronary calciumAbstract Acceptedluis afonso
Smith , KaylinDifferences between younger and older patients establishing care for HIV in Nashville Poster PresentedAnna Person
Strock, StephenDoes an intrinsic inherited characteristic, represented by HLA type, predispose individuals to excessive host reaction to histoplasmosis, manifested clinically as post-histoplasmosis fibrosing mediastinitis?Manuscript AcceptedJim Loyd

2016 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Al Aboud, Asad
Apple, Rachel
blaske, ashleyCreating an online educational module via VSTAR for interns rotating through the rheumatology clinic block. In ProgressSusan Kroop
Bregman, JanaValidation of photoscreening technology in the general pediatrics clinicManuscript PublishedSean P. Donahue
Metabologenomics of diabetic retinopathyPoster PresentedMilam Brantley
Scleral Lenses in Graft Versus Host DiseaseIn ProgressAnthony Daniels
Beyond CAUTIS: Additional Risks of Unnecessary Foley Catheter PlacementManuscript SubmittedCecelia Theobald
Bregman, Adam
Brown, Ryan
Burks, MargaretEffect of Socioeconomic Status on Care and Need for Medication Therapy in Women with Gestational Diabetes MellitusIn ProgressShubhada Jagasia
Recurrent Painless Thyroiditis with Sequential Thyrotoxicosis and Hypothyroidism After Two Courses of LenolidamideManuscript AcceptedShichun Bao
The 24 Hour Urine 5HIAA - A Simple Test with a Common PitfallManuscript AcceptedShichun Bao
Primary Hyperparathyrodism in a First Trimester Woman with Hyperemesis Gravidarum and PancreatitisManuscript AcceptedShichun Bao
Hyperglycemic Ketoacidosis in an Alcoholic: Diabetic Ketoacidosis versus Alcoholic KetoacidosisPoster PresentedGautam Bhave
Campbell, JessicaEffect that the palliative care unit has had on the MICU in terms of mortality, length of stay, etc. Abstract SubmittedMohana Karlekar and Art Wheeler
Christensen, April
Clark, DanPhenotypic variation of MHY7 gene leading to cardiomyopathiesIn ProgressDr. Jason Becker (Adult Cardiology)
Kawaski Disease - developing a predictive model for refractory KD and risk of developing giant coronary aneurysmsAbstract SubmittedDr. Natasha Halasa (Peds ID)
Global health: assessment of US Pediatric programs' utilization and efficacy of online modules for global health curricular developmentIn ProgressSuzinne Pak-Gornstein (UWashington Peds)
Chagas Reactivation in HIV+ patients - detecting parasitemia by a novel methodManuscript PublishedRobert H. Gilman
Twenty-Two kcal. Implementation and Evaluation of a Resident Driven Evidence-Based Pediatrics Educational InitiativeIn ProgressChristian Rosas-Salazar (Peds Pulm)
Racial Disparities with IVIG Response and Cardiac Involvement in Kawasaki DiseasePoster PresentedNatasha Halasa (Peds ID)
Cook, Christopher
Decker, IlkaSix-Minute Walk Test As a Measure of Functional Change after Chemotherapy in Cardiac AL AmyloidosisAbstract AcceptedRobert Cornell
Assessing chronic immune toxicities, health outcomes, and functional status among long term ipilimumab survivorsManuscript PublishedDouglas Johnson
Edwards, JadeAre pancreatic stents necessary to prevent post-ERCP pancreatitis following double-guidewire cannulation technique? In ProgressDr. Patrick Yachimski
Endsley, Whitney
Evans, KateDo baseline BNP levels differ between caucasians and African Americans?In ProgressDeepak Gupta
Flynn, JohnGenetic determinants of cd39 expression and platelet aggregation Poster PresentedRichard Gumina
Infectious complications of LVADsIn ProgressGowri Satyanarayana
Harris, Amanda
Heller, TysonIntraluminal impedance versus mucosal impedance testing for the diagnosis of GERD: do they measure the same thing? Poster PresentedMichael Vaezi
QI projects in vascular access and ECMO outcomesIn ProgressTodd Rice
Kapila, AtulReliability of diagnostic criteria for bronchiolitis obliterans syndrome after lung transplantation: a survey.Manuscript PublishedBhorade
Kim, Hannah
Kindle, RyanSecondary outcomes of thromboembolism prophylaxis decision support tools.In ProgressArt Wheeler
Lacy, MarianRisk Factors for for Missed Study Visits Among Patients with a Positive Screening Test for Latent Tuberculosis Infection (LTBI)Abstract SubmittedApril Pettit
Le, CatePost-operative outcomes in obese with patients with CTEPHPoster PresentedAnna Hemnes
Urine eicosanoids in HIV patientsIn ProgressTodd Hulgan
Urine eicosanoids in HIV patients, cross-sectional studyLecture PresentedTodd Hulgan
Cryptococcal meningitis outcomes in Latin America vs. VanderbiltAbstract SubmittedAnna Person
Leger, Paul
Leverenz, DavidWhat are the causes of elevated creatine kinase greater than 1,000 in patients referred for rheumatology consultation?Manuscript PublishedCecilia Chung
The Choosing Wisely daily labs initiative.Manuscript PublishedDonald Brady
An evaluation of patients homozygous and heterozygous for Pi*Z alpha-1 antitrypsin deficiency in BioVU.In ProgressJoshua Denny
Lombardi, Gilboa
Mashayekhi, MonaHistoplasmosis in kidney transplant recipientsIn ProgressAnthony Langone
McGuinn, Erin
McPherson, TristanHealth Literacy and associated outcomes in persons living with HIV. Determining if health literacy is associated with adverse outcomes in this population.In ProgressApril Pettit
Mitchell, Kevin
Naik, RishiCost of extraesophageal reflux diseaseIn ProgressDr. Vaezi
Myeloid translocation genes differentially regulate colorectal cancer programsManuscript PublishedDr. Williams
Methods to identify saline-contaminated electrolyte profilesManuscript PublishedDr. Vasilevskis
Utility of SI/SAP for patients with GERD s/p fundoplicationAbstract AcceptedDr. Vaezi
Quality of Life for women with rectovaginal fistulas: A comparison of IBD cohort versus Urology and Trauma patientsIn ProgressDr. Schwartz
Impact on the esophagus after bariatric sugeryManuscript PublishedDr. Vaezi
Impact of Weight Loss Surgery on Esophageal PhysiologyManuscript PublishedDr. Vaezi
MTG16 is a tumor suppressor in colitis-associated carcinomaManuscript SubmittedDr. Williams
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumorigenesisManuscript PublishedDr. Williams
Nesmith , NatalieFlu C In ProgressKeipp talbot
Nesmith, Natalie
Nguyen, Van1) Early Stage Hodgkin Lymphoma and the Role of XRT: a Look at OUtcomes 2) Paraprotein Gap: What Is Truly Elevated and What Medical Conditions Is It Associated With?In Progress1) Dr. Nishitha Reddy 2) Dr. Josh Denny
Ogunsile, Foluso
Patel, DanGastroesophageal Reflux Disease: Can we predict who will develop esophagitis?Poster PresentedMichael Vaezi
Esophageal acid exposure consistency as a measure of pH reliability: Should we abandon lower normative cutoffs?Manuscript SubmittedMichael Vaezi
Low distal contractile integral (DCI) on high resolution manometry is helpful in predicting an incomplete bolus transitPoster PresentedDonald Castell
Patel, Devin
perkins, katey
Phelps, Laura
Pointer, StephanieEvaluating the effect of high fat vs low fat diet on CRP and Apelin in obese African American and White WomenIn ProgressDr. Heidi Silver
Pointer, Stephanie
Richardson, TaylorTreatment of type 1 hepatorenal syndrome w norepinephrine Manuscript SubmittedMichael Porayko
Richardson, Crit
Shuxteau, JustinCarbon filament repairNot StartedS Walton
Sullivan, WilliamEvaluating Medical Students’ Use of Evidence-Based Medicine at the Point of Care: An OSCE-Based AssessmentManuscript PublishedJennifer Green and William Cutrer
Adequacy of Vaccinology Training During Pediatric Infectious Disease Fellowship.Poster PresentedBuddy Creech (Peds ID)
Twenty-Two kcal. Implementation and Evaluation of a Resident Driven Evidence-Based Pediatrics Educational INitiativePoster PresentedChristian Rosas-Salazar
Toward a Future of Expert Medical Educators: The MD/MEd Joint DegreeManuscript SubmittedBonnie M. Miller
Ukaegbu, OluchiAutologous Hematopoietic Cell Transplant Offers Prolonged Progression Free and Overall Survival in Patients with Light Chain AmyPoster PresentedFrank Cornell
Concurrent B-cell Follicular and Refractory CD30+ Large Cell Transformation ofManuscript PublishedNishitha Reddy
Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis With Prior exposure to JAK1/2 InhibitorManuscript PublishedBipin Savani
Impact of different mobilization methods on graft composition and outcome after autologous stem cell transplantationAbstract AcceptedStacey Goodman
Waterman, Brittany
Webb, Margaret
Wright, MeeraSelenium in IBd patients, Vitamin D deficiency in IBD patients, depression and compliance with Anti-TNF therapy in ibd patientsAbstract AcceptedSarah Horst
As aboveIn ProgressSarah Horst
Yoneda, ZachUtilization of electronic record linked genotype data to evaluate the pathogenicity of suspected familial cardiomyopathy DNA variantsAbstract SubmittedJason Becker
Common Genetic Variants and Response to Atrial Fibrillation AblationManuscript PublishedBen Shoemaker
The Effect of Atrial Fibrillation at the Time of Imaging on Measurement of Myocardial T1 TimeManuscript SubmittedBen Shoemaker
Zifodya, JerryCollagen V Autoantibodies as a risk factor for the development of Familial Interstitial PneumoniaIn ProgressJon Kropski
Nutritional Status of Patients with Idiopathic AchalasiaPoster PresentedMF Vaezi
The role of thymoglobulin in atherogenesisIn ProgressDr. JA Beckman & Dr. B Savani
Idiopathic (Primary) AchalasiaManuscript PublishedMF Vaezi

2017 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Armstrong, William
Bass, Jennifer
Brown, ChristopherDrive line infectionsManuscript PublishedHaglund
Marginal donor heart transplantManuscript PublishedHaglund
HypercalcemiaManuscript PublishedLindenfeld
Electrolyte managment in heart failureAbstract SubmittedLindenfeld, McPherson
ASCVD in chronic kidney disease, and Coronary Artery Calcium Score as Cardiovascular Risk Reclassification in this populationManuscript SubmittedAfonso
Bryant, Laura
Carpenter, KellyEvaluating internal medicine residents' knowledge of tuberculosis guidelinesIn ProgressGeorge Nelson
Clark, Sarah
Clark, Daniel
Clark, Charles
Cohen, Carolinecase control study- what factors are associated with nocardia infection in heart transplant patientsIn Progresslora thomas
Culhane, Dan
Denby, Kara
Desai, Megan
El Ramahi, Meral
Feld, EmilyMetastatic NSCLC and palliative care: Referral practices of medical oncologistsIn ProgressLeora Horn
'Melanoma-specific MHC-II expression represents a tumor-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy'Manuscript PublishedDoug Johnson
Optimizing melanoma treatment sequences: Anti-PD-1 before and after BRAF inhibition. Manuscript SubmittedDoug Johnson
Gabriel, Curtis
Gettler, Erin
Gonzalez, Karina
Grome, Heather
Gurwara, Shelly
Habegger, LukeLong QT Associated with Clindamycin in patient with Jervell and Lange-Nielsen SyndromeIn ProgressGregory, Shawn
Intern Code Training Simulation ResourcesIn ProgressMeredith Pugh
Harb, AliThe burden of bowel preparations in patients undergoing elective colonoscopyManuscript Published
Oropharyngeal Reflux Monitoring and Atypical Gastroesophageal Reflux Disease.Manuscript PublishedVaezi MF
Systematic review and meta-analysis: full- vs. half-dose anti-microbials in clarithromycin-based regimens for H pyloriManuscript PublishedAli Harb
Efficacy of reduced-dose regimen of a capsule containing bismuth, metronidazole, and tetracycline given with amoxicillinManuscript PublishedAla Sharara
Fecacrit: Derivation and Planned Validation of a Novel and Objective Tool for the Evaluation of High Quality Bowel PreparationAbstract Accepted
The Natural History of Incidental Colonic Diverticulosis on Screening Colonoscopy: A Prospective Cohort StudyAbstract Accepted
Low Prevalence of Hypomagnesemia in Long-term Recipients of Proton Pump Inhibitors in a Managed Care Cohort.Manuscript PublishedAla Sharara
Held, ElizabethCharacterizing the Metabolic Phenotype in Anthracycline CardiotoxicityIn ProgressQuinn Wells
Case Report: Neurosarcoidosis presenting as aseptic meningitis in an immunosuppressed renal transplant recipientManuscript SubmittedEdward Siew
Iglesia, Edward
Jones, Jade
Krill, JosephFactors Associated with Effectiveness of Antireflux Surgery for Extraesophageal RefluxLecture PresentedMichael Vaezi
Risk of cholecystitis after biliary stent placement for malignant distal biliary Manuscript SubmittedPatrick Yachimski
Increased risk of Pancreatitis following ERCP for Malignant Distal Biliary ObstructionPoster PresentedPatrick Yachimski
Clinical management of achalasia: current state of the art Manuscript PublishedMichael Vaezi
Law, Michelle
Leger, PaulWhether human genetic polymorphisms are associated with increased likelihood of Efavirenz and/or Atazanavir discontinuation.In ProgressDavid W. Haas, MD
Lester, Michael
Li, ZhuoyanOsteoporosis after HSCTIn ProgressBipin Savani
M Rubinstein, SamuelPathologic predictors of outcomes in renal AL amyloidosisAbstract AcceptedFrank Cornell, Agnes Fogo
Immune-mediated complications after hematopoietic stem cell transplantationManuscript PublishedBipin Savani
What is the optimal management of osteoporosis after stem cell transplant?In ProgressBipin Savani
Is anti-PD1 therapy safe and effective to administer in the elderly?Abstract SubmittedDouglas Johnson
Markham, NickDoes antibiotic use affect the progression of GERD to Barrett's Esophagus or esophageal adenocarcinoma?In ProgressPatrick Yachimski
Case Report: 56yo woman with IDDM and untreated PBC presented with recurrent DKA after many years of well-controlled blood sugar.In ProgressLawrence Wolfe
p120-catenin controls contractility along the vertical axis of epithelial lateral membranesManuscript SubmittedReynolds, Albert B.
Nickel, Nils
Patel, Neel
Reese, Tyler
Rice, SeanVideo on Diet Before Outpatient Colonoscopy Does Not Improve Quality of Bowel Preparation: A Prospective, Randomized, ControlledManuscript PublishedKeith Obstein
Evaluation of a novel tablet application for improvement in colonoscopy mentoring and proficiency in a clinical settingIn ProgressKeith Obstein
Riggins, Karen
Ritts, Alexandra
Rodriguez, Carmen
Rubinstein, Samuel
Ryan, MeganType II DM patients taking DPP-4 Inhibitors are more likely to have osteoporosis than those patients with type II DM not taking a DPP-4 IIn ProgressDr. Jessica Devin
Scott, Sarah
Sebold, Shayne
Skinner, ShannonProject is to improve Geriatric Curriculum for IM residents. Question will be if out educational intervention (inpatient rotation) improves residents' knowledge and attitudes about geriatricsIn ProgressMariu Carlo, Charlene Dewey
Sochacki, Andrew
Story, Ryan
Sullivan, Billy
Suojanen, Krista
Taylor, TrevorThe impact of obesity on the relationship between timing of enteral nutrition and outcomes in ARDSAbstract SubmittedTodd Rice
Tilden, DanDefining the phenotype of hypophosphatasia in adultsIn ProgressKathryn Dahir
Veazey, Stanton
Veazey, CrewsUtilization of repeat colonoscopy in LVAD patients who experience recurrent gastrointestinal bleeding.In ProgressReid Ness
Walker, Savannah
Welch, CaitlinEnd tidal CO2 as a predictor of outcomes in PAHManuscript SubmittedDr. Hemnes
Wilson, Matthew
Zeng, Lily
Zora, Greg

2018 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Alexander, Steven
Angiolillo, John
Arroyo, JP
Attia, Maggie
Bailin, Samual
Basdag, Basak
Boone, John
Cha, Jeeyeon
Christensen, Bradley
Chung, Jae
Conway, Ciara
Cook, Christine
Devolder, Jacob
French, John
Gao, ChanGenome-wide association study of rotator cuff tear Not StartedDr Nitin Jain
Gayle, Kathryn
Greco, Anthony
Hartman, Lauren
Honor, Ann
Jackson, Karen
Kennedy, Lucy
Kostelanetz , Sophia
Kozak, Patrick
Krebs, Adrienne
Lappas, Brian
Matthews, Juliana
Mozingo, Lauren
Nakajima, Erica
Norwood, Jamison
Penziner, Samuel
Roth, Marc
Sandvall, Breck
Schmeckpeper, Jeffery
Sinaise, Lanzi
Stephen, Mac
Thayer, Timothy
Vega-Velez, Jara
Watts, Gabe
White, Maya
Winters, Nikki
Wright, Jordan
Yang, Bin
Yang, Sushan

2019 Residents

Resident Name/InvestigatorProject Name/QuestionStatusMentor/Principal
Bock, Fabian
Edmonds, Peter

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